Synthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl--substituted amino- and 5-benzoyl--sulfonylamino-4-alkylsulfanyl-2-pyridones.

The present research describes the synthesis of novel 5-benzoyl--substituted-amino- and 5-benzoyl--sulfonylamino-4-alkylsulfanyl-2-pyridones - and - via the reaction of 2-benzoyl-3,3-bis(alkylthio)acrylonitriles - with -cyanoacetohydrazide and cyanoaceto--phenylsulfonylhydrazide , respectively. Also, the reactivity of the compounds - toward hydrazine hydrate to give product 1-pyrazolo[4,3-]pyridine derivative was studied. In addition, the reactivity of the - toward 1-cyanoacetyl-4 arylidenesemicarbazides - afforded 3,5-dihydro[1,2,4]triazolo[1,5-]pyridine-6-carbonitrile derivatives (-)-, which reacted with hydrazine hydrate to give 3-pyrazolo[4,3-][1,2,4]triazolo[1,5-]pyridine-6-carbonitrile derivatives -. The structures of the new products were characterized based on H nuclear magnetic resonance, C nuclear magnetic resonance, infrared, mass-spectroscopy, and elemental analyses. The products were screened in vitro for their antibacterial and antifungal activity properties.