Dahl Erika S, Aird Katherine M
Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, United States.
Front Oncol. 2017 Nov 29;7:291. doi: 10.3389/fonc.2017.00291. eCollection 2017.
The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.
共济失调毛细血管扩张症突变（ATM）蛋白激酶因其在DNA损伤反应中的作用及其与共济失调毛细血管扩张症疾病的关联而受到广泛研究。越来越多的证据表明，ATM在包括碳代谢在内的其他细胞过程中也发挥着重要作用。由于对细胞生物质的需求增加，癌症中的碳代谢高度失调。最近的一些研究报道了ATM在碳代谢调节中的非经典作用。本综述重点介绍了目前已知的ATM对碳代谢的调节、这些途径在癌症中的意义，以及开发ATM抑制剂作为癌症治疗策略的情况。
