脂肪细胞中2-脱氧-D-葡萄糖的积累：2-脱氧-D-葡萄糖与3-O-甲基-D-葡萄糖之间明显的转运差异。

2-Deoxy-D-glucose accumulation in adipocytes: apparent transport discrimination between 2-deoxy-D-glucose and 3-O-methyl-D-glucose.

作者信息

Thompson K A, Kleinzeller A

机构信息

Department of Physiology, University of Pennsylvania, Philadelphia 19104.

出版信息

Biochim Biophys Acta. 1989 Mar 28;1011(1):58-60. doi: 10.1016/0167-4889(89)90078-5.

DOI:10.1016/0167-4889(89)90078-5

PMID:2923870

Abstract

The uphill accumulation of free 2-deoxy-D-glucose and 2-deoxy-D-glucose 6-phosphate in rat adipocytes was found not to affect the steady-state distribution of 3-O-methyl-D-glucose although both hexoses share a common transport pathway. This observation argues against a possible effect of 2-deoxy-D-glucose phosphate on the equilibrating nature of the carrier. The results are discussed in light of hypotheses advanced to explain free 2-deoxy-D-glucose accumulation in a variety of cells.

摘要

尽管两种己糖共享一条共同的转运途径，但研究发现，大鼠脂肪细胞中游离的2-脱氧-D-葡萄糖和2-脱氧-D-葡萄糖6-磷酸的上坡积累并不影响3-O-甲基-D-葡萄糖的稳态分布。这一观察结果与2-脱氧-D-葡萄糖磷酸对载体平衡性质可能产生的影响相悖。根据为解释游离2-脱氧-D-葡萄糖在多种细胞中的积累而提出的假说，对这些结果进行了讨论。