采用伽玛刀立体定向放射外科治疗脑干转移瘤：印第安纳大学健康中心的经验。
Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience.
作者信息
Patel Ajay, Mohammadi Homan, Dong Tuo, Shiue Kevin Ren-Yeh, Frye Douglas, Le Yi, Ansari Shaheryar, Watson Gordon A, Miller James C, Lautenschlaeger Tim
机构信息
Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
CNS Oncol. 2018 Jan;7(1):15-23. doi: 10.2217/cns-2017-0029. Epub 2017 Dec 14.
Brainstem metastases offer a unique challenge in cancer treatment, yet stereotactic radiosurgery (SRS) has proven to be an effective modality in treating these tumors. This report discusses the clinical outcomes of patients with brainstem metastases treated at Indiana University with Gamma Knife (GK) radiosurgery from 2008 to 2016. 19 brainstem metastases from 14 patients who had follow-up brain imaging were identified. Median tumor volume was 0.04 cc (range: 0.01-2.0 cc). Median prescribed dose was 17.5 Gy to the 50% isodose line (range: 14-22 Gy). Median survival after GK SRS treatment to brainstem lesion was 17.2 months (range: 2.8-45.6 months). The experience at Indiana University confirms the safety and efficacy of range of GK SRS prescription doses (14-22 Gy) to brainstem metastases.
脑干转移瘤在癌症治疗中带来了独特的挑战，但立体定向放射外科手术（SRS）已被证明是治疗这些肿瘤的有效方式。本报告讨论了2008年至2016年在印第安纳大学接受伽玛刀（GK）放射外科治疗的脑干转移瘤患者的临床结果。从14例进行了随访脑部成像的患者中识别出19个脑干转移瘤。肿瘤体积中位数为0.04立方厘米（范围：0.01 - 2.0立方厘米）。至50%等剂量线的处方剂量中位数为17.5 Gy（范围：14 - 22 Gy）。GK SRS治疗脑干病变后的生存中位数为17.2个月（范围：2.8 - 45.6个月）。印第安纳大学的经验证实了GK SRS对脑干转移瘤的一系列处方剂量（14 - 22 Gy）的安全性和有效性。
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