Schnider S M, Kwong R H, Lenz F A, Kwan H C
Scientific Staff, Bell-Northern Research, Ottawa, Ontario, Canada.
Biol Cybern. 1989;60(3):203-12. doi: 10.1007/BF00207288.
An analysis method to detect the presence of feedback between biological signals, particularly those associated with the central nervous system, is presented. The technique is based on recent results in the system identification literature involving the concept of a feedback free process. It may be applied to volume conducted signals such as EEG and EMG, as well as to neuronal spike trains through the use of a data transformation procedure. The utility of the technique is then demonstrated in a study of the relationship between Parkinsonian tremor and certain tremor cells found in the thalamus of Parkinsonian patients, using data collected during thalamotomies. The results obtained suggest that feedback mechanisms may be an important factor contributing to Parkinsonian tremor.
本文提出了一种检测生物信号之间反馈存在的分析方法，特别是与中枢神经系统相关的信号。该技术基于系统识别文献中涉及无反馈过程概念的最新成果。它可应用于诸如脑电图（EEG）和肌电图（EMG）等容积传导信号，以及通过数据转换程序应用于神经元放电序列。然后，利用丘脑切开术期间收集的数据，在一项关于帕金森震颤与帕金森病患者丘脑中发现的某些震颤细胞之间关系的研究中证明了该技术的实用性。所获得的结果表明，反馈机制可能是导致帕金森震颤的一个重要因素。
