Nystoriak Matthew A, Navedo Manuel F
Department of Medicine, Diabetes and Obesity Center, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA.
Department of Pharmacology, University of California Davis, Davis, CA, USA.
Microcirculation. 2018 Jan;25(1). doi: 10.1111/micc.12435.
Arterial tone is tightly regulated by a variety of potassium (K ) permeable ion channels at the sarcolemma of vascular smooth muscle cells. In particular, several types of K channels provide a significant hyperpolarizing influence and serve to oppose pressure and agonist-induced membrane depolarization to promote smooth muscle relaxation and augmentation of vascular diameter and blood flow. In recent years, a number of studies have underscored previously unknown roles for particular K subunits, new modes of channel regulation, and distinct cellular functions for these channels during physiological and pathological conditions. In this overview, we highlight articles contained in this Special Topics Issue that focus on the latest, most exciting advancements in the field of K channels in the microcirculation. The collection of articles aims to highlight important new discoveries and controversies in the field of vascular K channels as well as to shed light on key questions that require additional investigation.
动脉张力由血管平滑肌细胞肌膜上的多种钾（K⁺）通透离子通道严格调控。特别是，几种类型的钾通道具有显著的超极化作用，可对抗压力和激动剂诱导的膜去极化，从而促进平滑肌舒张以及血管直径和血流量增加。近年来，大量研究强调了特定钾亚基以前未知的作用、通道调节的新模式以及这些通道在生理和病理条件下独特的细胞功能。在本综述中，我们重点介绍了本期专题中的文章，这些文章聚焦于微循环中钾通道领域最新、最令人兴奋的进展。这些文章旨在突出血管钾通道领域的重要新发现和争议，并阐明需要进一步研究的关键问题。
