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房室结折返性心动过速的替代治疗选择:急诊医学综述

Alternative Treatment Options for Atrioventricular-Nodal-Reentry Tachycardia: An Emergency Medicine Review.

作者信息

Brubaker Sarah, Long Brit, Koyfman Alex

机构信息

Department of Emergency Medicine, San Antonio Military Medical Center, Fort Sam Houston, Texas.

Department of Emergency Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.

出版信息

J Emerg Med. 2018 Feb;54(2):198-206. doi: 10.1016/j.jemermed.2017.10.003. Epub 2017 Nov 26.

DOI:10.1016/j.jemermed.2017.10.003
PMID:29239759
Abstract

BACKGROUND

Atrioventricular-nodal-reentry tachycardia (AVNRT) is a form of supraventricular tachycardia (SVT) that is relatively common in the emergency department (ED). It is rarely indicative of underlying electrical or structural pathology.

OBJECTIVE

This review evaluates the literature and controversies concerning treatment of AVNRT in the ED.

DISCUSSION

For treatment of narrow-complex tachycardia, Advanced Cardiovascular Life Support guidelines recommend the use of vagal maneuvers, followed by adenosine. Recent literature suggests that nondihydropyridine calcium channel blockers, such as verapamil and diltiazem, may be as effective as adenosine, without the negative short-term side effects. Multiple studies have demonstrated that although adenosine is rapid acting, there is no statistically significant difference in conversion rate between adenosine and calcium channel blockers. Both medications result in a conversion rate above 90%, but there are significantly more minor adverse effects, such as flushing or chest discomfort, with adenosine. Calcium channel blockers are a viable option for treatment for AVNRT, especially in refractory states. Beta-blockers have been evaluated but should not be used routinely due to lower efficacy. AVNRT is the most common tachydysrhythmia in pregnancy, and vagal maneuvers and adenosine are first line. Electrical cardioversion should be utilized for hemodynamically unstable patients. Most patients with AVNRT may be discharged with appropriate follow-up.

CONCLUSION

Several studies demonstrate that nondihydropyridine calcium channels (verapamil and diltiazem) are equally as efficacious as adenosine in converting AVNRT to sinus rhythm, without the negative (albeit short-lived) side effects. If given over 20 min, the risk for hypotension is low.

摘要

背景

房室结折返性心动过速(AVNRT)是室上性心动过速(SVT)的一种形式,在急诊科(ED)相对常见。它很少提示潜在的电学或结构病变。

目的

本综述评估有关急诊科AVNRT治疗的文献及争议。

讨论

对于窄QRS波心动过速的治疗,高级心血管生命支持指南推荐先采用迷走神经刺激手法,然后使用腺苷。近期文献表明,非二氢吡啶类钙通道阻滞剂,如维拉帕米和地尔硫䓬,可能与腺苷一样有效,且无短期不良反应。多项研究表明,尽管腺苷起效迅速,但腺苷与钙通道阻滞剂在转复率上无统计学显著差异。两种药物的转复率均高于90%,但腺苷的轻微不良反应,如面部潮红或胸部不适,明显更多。钙通道阻滞剂是治疗AVNRT的可行选择,尤其是在难治性状态下。β受体阻滞剂已被评估,但因其疗效较低不应常规使用。AVNRT是妊娠期间最常见的快速性心律失常,迷走神经刺激手法和腺苷是一线治疗方法。血流动力学不稳定的患者应采用电复律。大多数AVNRT患者经适当随访后可出院。

结论

多项研究表明,非二氢吡啶类钙通道阻滞剂(维拉帕米和地尔硫䓬)在将AVNRT转复为窦性心律方面与腺苷同样有效,且无负面(尽管是短暂的)副作用。如果给药时间超过20分钟,低血压风险较低。

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