Eurocat Northern Netherlands, Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Obstetrics and Gynaecology/Prenatal Diagnosis, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Prenat Diagn. 2018 Jan;38(2):130-134. doi: 10.1002/pd.5200. Epub 2018 Jan 4.
To describe prevalence, time of diagnosis, and type of birth in children and fetuses with urinary tract (UT) anomalies after the introduction of the anomaly scan in the Netherlands in 2007.
We selected, from a population-based congenital anomaly registry, children and fetuses with UT anomalies born between 2008 and 2014. Cases were defined according to type of UT anomaly and whether isolated or with associated anomalies. Information was collected on time of diagnosis and type of birth.
We included 487 cases. Total prevalence increased from 34.0 in 2008 to 42.3 per 10 000 births in 2014, mainly by an increase in anomalies of the collecting system. Almost 70% presented as isolated. Anomalies of the renal parenchyma were more often associated with genetic or other anomalies (47.3%) than anomalies of the collecting system (19.0%). The proportion of prenatally diagnosed cases increased from 59.3% in 2008 to 80.9% in 2014. Termination of pregnancy occurred in 14.8%, of which the majority were UT anomalies associated with a genetic disorder or other anomalies.
In the period after the introduction of the anomaly scan, we observed an increasing prevalence of anomalies of the collecting system, but no increase in termination of pregnancies.
描述 2007 年荷兰开展异常扫描后，儿童和胎儿尿路（UT）异常的流行率、诊断时间和分娩类型。
我们从基于人群的先天畸形登记处选择了 2008 年至 2014 年间出生的患有 UT 异常的儿童和胎儿。病例根据 UT 异常的类型以及是否为孤立性或伴有相关异常来定义。收集了诊断时间和分娩类型的信息。
我们纳入了 487 例病例。总患病率从 2008 年的 34.0/10000 增加到 2014 年的 42.3/10000，主要是由于集合系统异常的增加。近 70%为孤立性异常。肾实质异常与遗传或其他异常（47.3%）的相关性高于集合系统异常（19.0%）。产前诊断病例的比例从 2008 年的 59.3%增加到 2014 年的 80.9%。14.8%的病例终止了妊娠，其中大多数是与遗传疾病或其他异常相关的 UT 异常。
在开展异常扫描后，我们观察到集合系统异常的患病率增加，但终止妊娠的比例没有增加。
