Kaartinen Noora, Tinkanen Helena
Duodecim. 2017;133(8):728-34.
In Finland, the proportion of children born as a result of in vitro fertilization treatments is annually approximately 3.3%, and the percentage proportion of the population is growing. Their general somatic health status and cognitive development do not differ from spontaneously fertilized children. In vitro fertilization treatments are, however, associated with a slightly elevated risk of preterm delivery, low birth weight and structural abnormalities. The risk of childhood cancer does not appear to be increased in IVF children. The in vitro fertilization process affects the embryonic epigenome, which organizes itself during early embryonic development. These changes may influence the phenotype and health profile of the unborn child. The effect of in vitro fertilization treatments on an individual's long-term health is poorly understood, requiring prospective follow-up studies with sufficiently large datasets. In vitro fertilization treatments are the most effective way to treat infertility, and the treatments are generally safe both for the future mother and the baby being born.
在芬兰，通过体外受精治疗出生的儿童比例每年约为3.3%，且该比例在人口中呈增长趋势。他们的总体躯体健康状况和认知发育与自然受孕的儿童并无差异。然而，体外受精治疗与早产、低出生体重和结构异常的风险略有升高有关。体外受精儿童患儿童期癌症的风险似乎并未增加。体外受精过程会影响胚胎表观基因组，该基因组在胚胎早期发育过程中自行组织。这些变化可能会影响未出生胎儿的表型和健康状况。目前对体外受精治疗对个体长期健康的影响了解甚少，需要通过具有足够大样本量的前瞻性随访研究来进行探究。体外受精治疗是治疗不孕症最有效的方法，而且该治疗通常对未来母亲和即将出生的婴儿都是安全的。
