Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ewha Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
Yonsei University College of Medicine, Seoul, Republic of Korea.
Sci Rep. 2017 Dec 14;7(1):17612. doi: 10.1038/s41598-017-17909-7.
The Eph/ephrin receptor ligand system is known to play a role in inflammation induced by infection, injury, and inflammatory diseases. The present study aimed to evaluate plasma EphA2 receptor levels in critically ill patients with sepsis. This study was a prospective cohort study evaluating samples and clinical data from the medical intensive care unit (MICU) of a 2000-bed university tertiary referral hospital in South Korea. Positive correlations of the plasma EphA2 receptor level with the acute physiology and chronic health evaluation (APACHE) II score and the sequential organ failure assessment (SOFA) score were observed. The area under the curve (AUC) for the plasma EphA2 receptor level on a receiver operating characteristic curve was 0.690 (95% confidence interval [CI], 0.608-0.764); the AUCs for the APACHE II score and SOFA scores were 0.659 (95% CI, 0.576-0.736) and 0.745 (95% CI, 0.666-0.814), respectively. A Cox proportional hazard model identified an association between an increased plasma EphA2 receptor level (>51.5 pg mL) and increased risk of 28-day mortality in the MICU (hazard ratio = 3.22, 95% CI, 1.709-6.049). An increased plasma EphA2 receptor level was associated with sepsis severity and 28-day mortality among sepsis patients.
Eph/ephrin 受体配体系统已知在感染、损伤和炎症性疾病引起的炎症中发挥作用。本研究旨在评估脓毒症重症患者的血浆 EphA2 受体水平。本研究是一项前瞻性队列研究，评估了来自韩国一家 2000 张床位的大学三级转诊医院的内科重症监护病房（MICU）的样本和临床数据。观察到血浆 EphA2 受体水平与急性生理学和慢性健康评估 (APACHE) II 评分和序贯器官衰竭评估 (SOFA) 评分呈正相关。受试者工作特征曲线下的血浆 EphA2 受体水平曲线下面积为 0.690（95%置信区间 [CI]，0.608-0.764）；APACHE II 评分和 SOFA 评分的 AUC 分别为 0.659（95%CI，0.576-0.736）和 0.745（95%CI，0.666-0.814）。Cox 比例风险模型确定，血浆 EphA2 受体水平升高（>51.5pg/mL）与 MICU 28 天死亡率升高相关（风险比=3.22，95%CI，1.709-6.049）。在脓毒症患者中，血浆 EphA2 受体水平升高与脓毒症严重程度和 28 天死亡率相关。
