Zuo Zhi-Yan, Zhan Shu-Yu, Huang Xuan, Ding Bao-Yue, Liu Yu-Qian, Ruan Yu-Er, Jiang Ning-Hua
Medical College of Jiaxing University, Jiaxing 314001, China.
The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China.
Zhongguo Zhong Yao Za Zhi. 2017 Oct;42(20):3860-3865. doi: 10.19540/j.cnki.cjcmm.2017.0153.
Total glucosides of peony (TGP), containing the effective components of paeoniflorin (Pae), albiflorin (Alb) and so on, are effective parts of Radix Paeoniae Alba. And it possesses extensive pharmacological actions, one of which is hepatoprotective effect. In recent years, abundant of pharmacokinetics and pharmacodynamics research of TGP in hepatoprotective effects have been performed. However, the relative medicine of TGP in hepatoprotective effect has not been developed for clinical application. In order to provide reference for the development and rational clinical application of TGP, the research progresses of pharmacokinetics and pharmacodynamics of TGP in hepatoprotective effect were summarized in this paper. Pharmacokinetics research has clarified the process of absorption, distribution, metabolism and excretion of TGP in vivo, and liver injury disease can significantly influence its metabolic processes. Pharmacodynamics studies suggested that TGP can protect against acute liver injury, non-alcoholic fatty liver diseases (NAFLD), chronic liver fibrosis and liver cancer. However, the action mechanism and in vivo process about hepatoprotective effects of TGP have not been clearly revealed. How liver injury influences the metabolism of TGP and its integrated regulation through multiple targets need to be further studied. The combined pharmacokinetics and pharmacodynamics studies should be performed in favour of medicine development and clinical application of TGP in hepatoprotective effects.
芍药总苷（TGP）含有芍药苷（Pae）、 albiflorin（Alb）等有效成分，是白芍的有效部位。它具有广泛的药理作用，其中之一是保肝作用。近年来，对TGP保肝作用进行了大量的药代动力学和药效学研究。然而，TGP保肝作用的相关药物尚未开发用于临床应用。为了为TGP的开发和合理临床应用提供参考，本文总结了TGP保肝作用的药代动力学和药效学研究进展。药代动力学研究阐明了TGP在体内的吸收、分布、代谢和排泄过程，肝损伤疾病可显著影响其代谢过程。药效学研究表明，TGP可预防急性肝损伤、非酒精性脂肪性肝病（NAFLD）、慢性肝纤维化和肝癌。然而，TGP保肝作用的作用机制和体内过程尚未明确揭示。肝损伤如何影响TGP的代谢及其通过多个靶点的综合调控有待进一步研究。联合进行药代动力学和药效学研究有利于TGP保肝作用的药物开发和临床应用。
