全羽扇豆（白羽扇豆）种子及其蛋白质分离物的降胆固醇作用。

Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate.

作者信息

Fontanari Gustavo Guadagnucci, Batistuti José Paschoal, Cruz Robison José da, Saldiva Paulo Hilário Nascimento, Arêas José Alfredo Gomes

机构信息

Faculdade de Ciências Farmacêuticas, Departamento de Alimentos e Nutrição, CEP 14801-902, UNESP, Araraquara, SP, Brazil; Departamento de Nutrição, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Doutor Arnaldo 715, 01246-904 São Paulo, Brazil.

Faculdade de Ciências Farmacêuticas, Departamento de Alimentos e Nutrição, CEP 14801-902, UNESP, Araraquara, SP, Brazil.

出版信息

Food Chem. 2012 Jun 1;132(3):1521-1526. doi: 10.1016/j.foodchem.2011.11.145. Epub 2011 Dec 13.

DOI:10.1016/j.foodchem.2011.11.145

PMID:29243644

Abstract

This study describes the hypocholesterolaemic effect of whole lupin and its protein in hamsters. The diets were: casein (control group HC), lupin protein isolate (group HPI) and whole lupin seed (group HWS). Diets from HPI and HWS promoted a significant reduction of total cholesterol and non-HDL cholesterol in the hamsters' plasma as compared with HC. The true digestibility of HPI and HC groups were similar and differed significantly from the HWS one, which in turn showed a significant difference in total sterol excretion as compared to the former groups. Histological analysis of the liver revealed that animals fed on HPI and HWS diets presented a low level of steatosis (level 1) as compared to the ones fed on HC diet (level 4). Our findings demonstrate that protein isolate from Lupinus albus from Brazil has a metabolic effect on endogenous cholesterol metabolism and a protector effect on development of hepatic steatosis.

摘要

本研究描述了全羽扇豆及其蛋白质对仓鼠的降胆固醇作用。饮食组分别为：酪蛋白（对照组HC）、羽扇豆分离蛋白（HPI组）和全羽扇豆种子（HWS组）。与HC组相比，HPI组和HWS组的饮食使仓鼠血浆中的总胆固醇和非高密度脂蛋白胆固醇显著降低。HPI组和HC组的真消化率相似，与HWS组有显著差异，而HWS组与前两组相比，总甾醇排泄有显著差异。肝脏组织学分析显示，与喂食HC饮食的动物（4级）相比，喂食HPI和HWS饮食的动物脂肪变性水平较低（1级）。我们的研究结果表明，来自巴西的白羽扇豆分离蛋白对内源性胆固醇代谢具有代谢作用，对肝脂肪变性的发展具有保护作用。