嵌合抗原受体 T 细胞（CAR T 细胞）。
CD19 CAR T Cells.
机构信息
Center for Cell Engineering, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.
出版信息
Cell. 2017 Dec 14;171(7):1471. doi: 10.1016/j.cell.2017.12.002.
CARs are synthetic receptors that reprogram immune cells for therapeutic purposes. They comprise three canonical domains for antigen recognition, T cell activation, and costimulation. The CAR cDNA is genetically integrated in the T cell genome. Autologous CAR T cells are generated from the patient's peripheral blood T cells and expand in the recipient to eliminate the targeted tumor. To view this Bench to Bedside, open or download the PDF.
嵌合抗原受体（CARs）是一种用于治疗目的的免疫细胞重编程的人工受体。它由三个用于抗原识别、T 细胞激活和共刺激的典型结构域组成。CAR cDNA 被遗传整合到 T 细胞基因组中。自体 CAR T 细胞是从患者外周血 T 细胞中产生的，并在受体中扩增以消除靶向肿瘤。要查看此从实验室到临床的转化，请打开或下载 PDF。
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