Allolio B, Jaursch-Hancke C, Reincke M, Arlt W, Metzler U, Winkelmann W
Medizinische Universitätsklinik II und Poliklinik, Köln.
Dtsch Med Wochenschr. 1989 Mar 10;114(10):381-4. doi: 10.1055/s-2008-1066605.
A right adrenocortical carcinoma (weighing 978 g) was removed from a 45-year-old man in April 1986, the tumour bed then being irradiated with 40 Gy. Subsequently discovered multiple lung metastases were treated with cisplatin, etoposide and bleomycin, without improvement. Treatment with mitotane (Lysodren) was also without effect and had to be discontinued because of severe side effects. Treatment with suramin (Germanin) was begun in August 1987. After a loading dose of 10.7 g for six weeks the lung metastases regressed almost completely. But lung metastases were again demonstrated in January 1988 during a low-dose maintenance regimen of suramin. Increased dosage arrested further growth, but achieved no regression of the metastases. The patient died unexpectedly in April 1988 of acute circulatory failure. Suramin administration had been discontinued six weeks earlier because of bronchopneumonia and general deterioration. Thrombocytopenia, coagulation disorders and moderate proteinuria were the side effects of suramin treatment.
1986年4月，从一名45岁男性身上切除了一个重978克的右肾上腺皮质癌，随后肿瘤床接受了40戈瑞的放射治疗。随后发现的多发性肺转移瘤采用顺铂、依托泊苷和博来霉素治疗，病情无改善。米托坦（Lysodren）治疗也无效，且因严重副作用不得不停药。1987年8月开始使用苏拉明（Germanin）治疗。在给予10.7克的负荷剂量持续六周后，肺转移瘤几乎完全消退。但在1988年1月苏拉明低剂量维持治疗期间，再次发现肺转移瘤。增加剂量阻止了转移瘤的进一步生长，但未能使其消退。该患者于1988年4月意外死于急性循环衰竭。由于支气管肺炎和全身状况恶化，苏拉明给药已在六周前停止。血小板减少、凝血障碍和中度蛋白尿是苏拉明治疗的副作用。
