Vartanian N L, Luganova I S, Blinov M N
Eksp Onkol. 1989;11(1):43-5.
The results of study of NKC activity (51Cr release assay, conjugate-forming and lytic activity) in healthy persons and patients with acute leukemia (AL) in active phase and in remission are presented. It has been shown that the depression of the NKC activity in acute phase of AL (6 times as low as in norm) and in remission (3 times as low as in norm) depended upon disturbances of the processes of conjugate formation, lytic and recycling activity. Correlation has been found between percentage of lytic conjugates and that of cytotoxicity. The increase of NKC activity in remission seemed to be due to tendency to normalization of functional state of NK-cells (conjugate-forming and recycling activity).
本文展示了对健康人、急性期和缓解期急性白血病（AL）患者自然杀伤细胞（NKC）活性（51Cr释放试验、结合形成和溶解活性）的研究结果。结果表明，AL急性期（比正常水平低6倍）和缓解期（比正常水平低3倍）NKC活性的降低取决于结合形成、溶解和再循环活性过程的紊乱。已发现溶解结合物百分比与细胞毒性百分比之间存在相关性。缓解期NKC活性的增加似乎是由于NK细胞功能状态（结合形成和再循环活性）趋于正常化。
