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外用药物的合理处方与应用:如何计算所需软膏处方的正确用量?

[Adequate prescription and application of topicals : How to calculate the right volume for the prescription of ointment needed?].

作者信息

Homayoon D, Dahlhoff P, Augustin M

机构信息

Institut für Versorgungsforschung in der Dermatologie und bei Pflegeberufen (IVDP), Universitätsklinikum Hamburg-Eppendorf (UKE), Martinistr. 52, 20246, Hamburg, Deutschland.

出版信息

Hautarzt. 2018 Jun;69(6):478-483. doi: 10.1007/s00105-017-4088-z.

DOI:10.1007/s00105-017-4088-z
PMID:29247255
Abstract

BACKGROUND

Uncertainty regarding the suitable amount of prescribed ointment and its application by patients may cause insufficient or uneconomic health care provision. To address this issue, standardized methods and experts' knowledge on the suitable amount and coherent patient's elucidation for application of topicals are needed.

OBJECTIVES

Presented are current data in routine care and scientific evidence on the prescribed amount of topical agents as well as its application by patients in dermatological care.

MATERIALS AND METHODS

A literature review was conducted via PubMed using the keywords as individual and pooled search terms: "local therapy", "topical treatment", "prescription", "amount of ointment needed", "involved area", "BSA", "finger-tip-unit", "Rule of Hand", "calculated dosage" and "rule of nines". We included original studies by manually screening title and abstract according to the relevance of the topic.

RESULTS

The search strategy identified 19 clinical trials. The fingertip unit (FTU) is the most frequently used measurement for accurate application of external agents. Appropriate prescribed amount is calculated by required topical agent per involved surface area.

CONCLUSIONS

There is still a need for clarification to which extent the optimized amount of ointment is prescribed and advice for its application in routine care is given. The FTU combined with the "Rule of Hand" is an adequate measurement for patient's guidance on self-application.

摘要

背景

患者对于规定药膏用量及其使用方法存在不确定性,这可能导致医疗保健供应不足或不经济。为解决这一问题,需要标准化方法以及专家关于合适用量的知识,并对患者进行连贯的外用药物使用说明。

目的

介绍皮肤科护理中局部用药规定用量以及患者使用情况的常规护理和科学证据中的当前数据。

材料与方法

通过PubMed进行文献综述,使用关键词作为单独和汇总搜索词:“局部治疗”“外用治疗”“处方”“所需药膏量”“受累面积”“体表面积”“指尖单位”“手部规则”“计算剂量”和“九分法”。我们根据主题相关性通过手动筛选标题和摘要纳入了原始研究。

结果

搜索策略确定了19项临床试验。指尖单位(FTU)是最常用于准确外用药物的测量方法。合适的规定用量通过每受累表面积所需的外用药物来计算。

结论

仍需要明确在多大程度上规定了优化的药膏用量,并在常规护理中给出其使用建议。FTU与“手部规则”相结合是指导患者自我用药的适当测量方法。

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1
[Adequate prescription and application of topicals : How to calculate the right volume for the prescription of ointment needed?].外用药物的合理处方与应用:如何计算所需软膏处方的正确用量?
Hautarzt. 2018 Jun;69(6):478-483. doi: 10.1007/s00105-017-4088-z.
2
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本文引用的文献

1
A Topical Treatment Optimization Programme (TTOP) improves clinical outcome for calcipotriol/betamethasone gel in psoriasis: results of a 64-week multinational randomized phase IV study in 1790 patients (PSO-TOP).一项局部治疗优化方案(TTOP)改善了钙泊三醇/倍他米松凝胶治疗银屑病的临床疗效:一项在 1790 例患者中进行的为期 64 周的多国、随机、四期研究(PSO-TOP)结果。
Br J Dermatol. 2017 Jul;177(1):197-205. doi: 10.1111/bjd.15466. Epub 2017 Jun 6.
2
Are we giving patients enough information on how to use topical treatments? Analysis of 767 prescriptions in psoriasis.我们是否向患者提供了足够的关于如何使用局部治疗的信息?767 例银屑病处方分析。
Br J Dermatol. 2011 Dec;165(6):1332-6. doi: 10.1111/j.1365-2133.2011.10480.x. Epub 2011 Oct 17.
3
A prospective study of patient adherence to topical treatments: 95% of patients underdose.
一项关于患者局部治疗依从性的前瞻性研究:95%的患者用药剂量不足。
J Am Acad Dermatol. 2008 Dec;59(6):975-80. doi: 10.1016/j.jaad.2008.07.039. Epub 2008 Sep 24.
4
Expert consensus: time for a change in the way we advise our patients to use topical corticosteroids.专家共识:是时候改变我们建议患者使用外用糖皮质激素的方式了。
Br J Dermatol. 2008 May;158(5):917-20. doi: 10.1111/j.1365-2133.2008.08479.x. Epub 2008 Feb 22.
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The fingertip unit: A practical guide to topical therapy in children.指尖单元:儿童局部治疗实用指南。
J Dermatolog Treat. 2007;18(5):319-20. doi: 10.1080/09546630701441723.
6
How much of a topical agent should be prescribed for children of different sizes?对于不同体型的儿童,应该开具多少剂量的局部用药呢?
J Dermatolog Treat. 2006;17(4):224-8. doi: 10.1080/09546630600894998.
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[Analysis of the digital unit as reference measurement for the topical prescription in Mexico].[墨西哥局部用药处方参考测量的数字单位分析]
Gac Med Mex. 2006 Jan-Feb;142(1):35-8.
8
The right dose in the right place: an overview of current prescription, instruction and application modalities for topical psoriasis treatments.正确剂量用于正确部位:银屑病局部治疗的当前处方、说明及应用方式概述
J Eur Acad Dermatol Venereol. 2005 Nov;19 Suppl 3:14-7. doi: 10.1111/j.1468-3083.2005.01333.x.
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THE WEIGHTS OF TOPICAL PREPARATIONS REQUIRED FOR TOTAL AND PARTIAL BODY INUNCTION.
J Invest Dermatol. 1964 Mar;42:253-6. doi: 10.1038/jid.1964.57.
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Determination of human body surface area from height and weight.根据身高和体重测定人体表面积。
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