Department of Radiology, Wayne State University School of Medicine, 4201 St. Antoine, Detroit, MI, 48201, USA.
Department of Biomedical Engineering, Wayne State University College of Engineering, Detroit, MI, USA.
Eur Radiol. 2018 May;28(5):1884-1890. doi: 10.1007/s00330-017-5160-x. Epub 2017 Dec 15.
To evaluate the magnetic susceptibility, ∆χ , as a surrogate marker of venous blood oxygen saturation, S O , in second- and third-trimester normal human foetuses.
Thirty-six pregnant women, having a mean gestational age (GA) of 31 2/7 weeks, underwent magnetic resonance imaging (MRI). Susceptibility-weighted imaging (SWI) data from the foetal brain were acquired. ∆χ of the superior sagittal sinus (SSS) was quantified using MR susceptometry from the intra-vascular phase measurements. Assuming the magnetic property of foetal blood, ∆χ , is the same as that of adult blood, S O was derived from the measured Δχ . The variation of ∆χ and S O , as a function of GA, was statistically evaluated.
The mean ∆χ in the SSS in the second-trimester (n = 8) and third-trimester foetuses (n = 28) was found to be 0.34± 0.06 ppm and 0.49 ±0.05 ppm, respectively. Correspondingly, the derived S O values were 69.4% ±3.27% and 62.6% ±3.25%. Although not statistically significant, an increasing trend (p = 0.08) in Δχ and a decreasing trend (p = 0.22) in S O with respect to advancing gestation was observed.
We report cerebral venous blood magnetic susceptibility and putative oxygen saturation in healthy human foetuses. Cerebral oxygen saturation in healthy human foetuses, despite a slight decreasing trend, does not change significantly with advancing gestation.
• Cerebral venous magnetic susceptibility and oxygenation in human foetuses can be quantified. • Cerebral venous oxygenation was not different between second- and third-trimester foetuses. • Foetal cerebral venous oxygenation does not change significantly with advancing gestation.
评估磁化率 ∆χ 作为第二和第三孕期正常胎儿静脉血氧饱和度 S O 的替代标志物。
36 名孕妇的平均孕龄（GA）为 31 2/7 周，进行了磁共振成像（MRI）检查。从胎儿大脑中获取了磁化率加权成像（SWI）数据。使用 MR 磁化率法从血管内相测量中量化了上矢状窦（SSS）的 ∆χ。假设胎儿血液的磁性特性 ∆χ 与成人血液相同，从测量的 ∆χ 中得出 S O 。统计评估了 ∆χ 和 S O 随 GA 的变化。
第二孕期（n = 8）和第三孕期胎儿（n = 28）SSS 中的平均 ∆χ 分别为 0.34±0.06 ppm 和 0.49 ±0.05 ppm。相应地，得出的 S O 值分别为 69.4% ±3.27%和 62.6% ±3.25%。尽管没有统计学意义，但观察到 ∆χ 呈增加趋势（p = 0.08），S O 呈下降趋势（p = 0.22），随着妊娠的进展而变化。
我们报告了健康胎儿大脑静脉的血液磁化率和潜在的氧饱和度。健康胎儿大脑的氧饱和度尽管有轻微的下降趋势，但随着妊娠的进展并没有显著变化。
可以量化人类胎儿大脑静脉的磁化率和氧合作用。
第二和第三孕期胎儿大脑静脉的氧合作用没有差异。
胎儿大脑静脉的氧合作用随着胎龄的增加没有显著变化。
