Webster A, Mawer G E
Manchester Royal Infirmary, England.
Epilepsia. 1989 Mar-Apr;30(2):162-7. doi: 10.1111/j.1528-1157.1989.tb05449.x.
A group of 18 patients with chronic epilepsy were followed in an outpatient clinic for 1-6 years. Month-by-month seizure records were kept and the response to treatment was systematically explored. The present study was prompted when three patients became seizure-free, apparently in response to major life events (marriage, parenthood, and retirement) rather than to changes in treatment. All the subjects were interviewed in their own homes with a companion, friend, or relative present. The interview was based on a standard instrument (Life Experiences Survey, LES). The home environment was chosen to facilitate recall of events and to enable subjects to confirm dates. The seizure record was then compared with the parallel life events record. Two methods of analysis were adopted. In the first, each life event was assumed to have impact on seizure frequency only during the month in which it occurred; life event months were compared with non-life-event months. In the second, a life event was considered a watershed; seizure frequencies before and after the event were compared. Nonparametric statistical methods were used. These approaches revealed associations between life events and seizure frequency in three additional patients (total six). Most of the patients who showed an association experienced partial seizures.
一组18名慢性癫痫患者在门诊接受了1至6年的随访。逐月记录癫痫发作情况，并系统地探讨治疗反应。当三名患者显然因重大生活事件（结婚、为人父母和退休）而非治疗变化而无癫痫发作时，促使了本研究的开展。所有受试者均在有同伴、朋友或亲属在场的情况下在其家中接受访谈。访谈基于一种标准工具（生活经历调查，LES）。选择在家中进行访谈是为了便于回忆事件，并使受试者能够确认日期。然后将癫痫发作记录与同期的生活事件记录进行比较。采用了两种分析方法。第一种方法是，假定每个生活事件仅在其发生的月份对癫痫发作频率有影响；将有生活事件的月份与无生活事件的月份进行比较。第二种方法是，将一个生活事件视为一个分水岭；比较事件前后的癫痫发作频率。使用了非参数统计方法。这些方法在另外三名患者（共六名）中揭示了生活事件与癫痫发作频率之间的关联。大多数显示出关联的患者经历的是部分性癫痫发作。
