Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Department of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Exp Dermatol. 2018 Feb;27(2):178-184. doi: 10.1111/exd.13484. Epub 2018 Jan 9.
Psoriasis, a chronic inflammatory skin disease, is closely related to systemic metabolism. An elevated body mass index (BMI) is a risk factor for psoriasis; inflammasomes are activated by adipose tissue macrophages in obese subjects. We hypothesized that hyperlipidaemia is involved in the pathogenesis of psoriasis and examined the role of a high-fat diet (HFD) in the development of psoriasis in imiquimod (IMQ)-treated mice. The body weight and serum level of cholesterol were significantly higher in mice fed an HFD than in a regular diet (RD). HFD mice had higher psoriasis skin scores, and the number of neutrophils infiltrating into the lesional skin was elevated. IL-17A mRNA expression was significantly increased in the skin of IMQ-treated HFD mice; the expression of IL-22, IL-23 and TNF-α mRNA was not enhanced. Caspase-1 and IL-1β were activated in the skin of IMQ-treated HFD mice, and their serum level of IL-17A, TNF-α and IL-1β was significantly upregulated. Our findings strongly suggest that hyperlipidaemia is involved in the development and progression of psoriasis via systemic inflammation and inflammasome activation.
银屑病是一种慢性炎症性皮肤病，与全身代谢密切相关。肥胖是银屑病的一个危险因素；肥胖者的脂肪组织巨噬细胞会激活炎症小体。我们假设高脂血症参与了银屑病的发病机制，并研究了高脂肪饮食（HFD）在咪喹莫特（IMQ）处理的小鼠银屑病发展中的作用。与正常饮食（RD）相比，HFD 喂养的小鼠体重和血清胆固醇水平显著升高。HFD 小鼠的银屑病皮肤评分更高，并且浸润到病变皮肤的中性粒细胞数量增加。IMQ 处理的 HFD 小鼠皮肤中 IL-17A mRNA 的表达显著增加；IL-22、IL-23 和 TNF-α mRNA 的表达没有增强。IMQ 处理的 HFD 小鼠皮肤中 caspase-1 和 IL-1β 被激活，其血清中 IL-17A、TNF-α 和 IL-1β 的水平显著上调。我们的研究结果强烈表明，高脂血症通过全身炎症和炎症小体激活参与了银屑病的发生和发展。
