Nie Jinlei, Zhang Haifeng, Kong Zhaowei, George Keith, Little Jonathan P, Tong Tomas K, Li Feifei, Shi Qingde
School of Physical Education and Sports, Macao Polytechnic Institute, Macao, China.
College of Physical Education, Hebei Normal University, Hebei, China.
Exp Physiol. 2018 Mar 1;103(3):370-380. doi: 10.1113/EP086767. Epub 2018 Jan 16.
What is the central question of this study? Does exercise training impact resting and postexercise cardiac troponin T (cTnT) concentration? What is the main finding and its importance? This randomized controlled intervention study demonstrated that 12 weeks of either high-intensity interval training or moderate-intensity continuous training largely abolished the exercise-induced elevation in cTnT when exercise was performed at the same absolute intensity. There was no impact of training on resting cTnT or postexercise appearance of cTnT when exercise was performed at the same relative intensity. These findings provide new information that might help clinicians with decision-making in relationship to basal and postexercise values of cTnT in individuals with different training status.
We evaluated the influence of 12 weeks of high-intensity interval training [HIIT; repeated 4 min cycling at 90% of maximal oxygen uptake (V̇O2max) interspersed with 3 min rest, 200-300 kJ per session, 3 or 4 days each week] and work-equivalent moderate-intensity continuous training (MICT; continuous cycling at 60% V̇O2max) on resting cardiac troponin T (cTnT) and the appearance of exercise-induced cTnT. Forty-eight sedentary obese young women were randomly assigned to HIIT, MICT or a control group. The V̇O2max and body composition were measured before and after training. At baseline, cTnT was assessed using a high-sensitivity assay at rest and immediately, 2 and 4 h after 45 min cycling at 60% V̇O2max. After a 12 week training period, cTnT was assessed before and after 45 min cycling at the same relative and absolute intensities as before training. Training led to higher V̇O2max and lower fat mass in both HIIT and MICT groups (all P < 0.05). Before training, cTnT was significantly elevated in all three groups (by 35-118%, all P < 0.05) with acute exercise. After training, both resting and postexercise cTnT concentrations (same relative intensity) were similar to pretraining values. In contrast, postexercise cTnT (same absolute intensity, which represented a smaller exercise stimulus) was not elevated from rest in both HIIT and MICT groups. In conclusion, 12 weeks of either HIIT or MICT largely abolished the postexercise elevation of cTnT concentration when exercise was performed at the same absolute intensity. There was, however, no impact of training on resting cTnT or postexercise appearance of cTnT for exercise performed at the same relative intensity.
本研究的核心问题是什么？运动训练是否会影响静息和运动后心肌肌钙蛋白T（cTnT）浓度？主要发现及其重要性是什么？这项随机对照干预研究表明，当以相同的绝对强度进行运动时，12周的高强度间歇训练或中等强度持续训练在很大程度上消除了运动诱导的cTnT升高。当以相同的相对强度进行运动时，训练对静息cTnT或运动后cTnT的出现没有影响。这些发现提供了新的信息，可能有助于临床医生针对不同训练状态个体的cTnT基础值和运动后值进行决策。
我们评估了12周的高强度间歇训练[HIIT；以最大摄氧量（V̇O2max）的90%重复进行4分钟骑行，中间穿插3分钟休息，每次训练200 - 300千焦，每周3或4天]和等效工作量的中等强度持续训练（MICT；以V̇O2max的60%持续骑行）对静息心肌肌钙蛋白T（cTnT）以及运动诱导的cTnT出现情况的影响。48名久坐不动的肥胖年轻女性被随机分配到HIIT组、MICT组或对照组。在训练前后测量V̇O2max和身体成分。在基线时，使用高灵敏度检测法在静息状态下以及在以V̇O2max的60%进行45分钟骑行后即刻、2小时和4小时评估cTnT。经过12周的训练期后，在与训练前相同的相对和绝对强度下进行45分钟骑行前后评估cTnT。训练使HIIT组和MICT组的V̇O2max升高且脂肪量降低（所有P < 0.05）。训练前，所有三组在急性运动后cTnT均显著升高（升高35 - 118%，所有P < 0.05）。训练后，静息和运动后cTnT浓度（相同相对强度）与训练前值相似。相比之下，在HIIT组和MICT组中，运动后cTnT（相同绝对强度，代表较小的运动刺激）并未高于静息水平。总之，当以相同的绝对强度进行运动时，12周的HIIT或MICT在很大程度上消除了运动后cTnT浓度的升高。然而，当以相同的相对强度进行运动时，训练对静息cTnT或运动后cTnT的出现没有影响。
