唾液酸神经酰胺（GM4）及其NeuAc(α2----3)Galβ糖成分的溶液构象。
Solution conformation of sialosylcerebroside (GM4) and its NeuAc(alpha 2----3)Gal beta sugar component.
作者信息
Poppe L, Dabrowski J, von der Lieth C W, Numata M, Ogawa T
机构信息
Max-Planck-Institut für Medizinische Forschung, Heidelberg, Federal Republic of Germany.
出版信息
Eur J Biochem. 1989 Mar 15;180(2):337-42. doi: 10.1111/j.1432-1033.1989.tb14653.x.
The solution conformations of GM4 ganglioside [NeuAc(alpha 2----3)Gal (beta 1----1)Cer] in (2H3C)2SO and its component disaccharide in 2H2O were investigated with the aid of 1H-nuclear magnetic resonance spectroscopy (nuclear Overhauser effect, analysis of coupling constants) and by energy-minimum calculations. The existence of three low-energy conformers obtained by theoretical calculations was supported by experimental findings in the case of GM4, whereas the disaccharide appears to exist as a mixture of two conformers.
借助氢核磁共振光谱法（核Overhauser效应、耦合常数分析）并通过能量最小化计算，研究了神经节苷脂GM4[NeuAc(α2→3)Gal(β1→1)Cer]在(2H3C)2SO中的溶液构象及其二糖组分在2H2O中的溶液构象。对于GM4，理论计算得到的三种低能构象的存在得到了实验结果的支持，而二糖似乎以两种构象的混合物形式存在。
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