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Three-dimensional structure of the oligosaccharide terminus of globotriaosylceramide and isoglobotriaosylceramide in solution. A rotating-frame NOE study using hydroxyl groups as long-range sensors in conformational analysis by 1H-NMR spectroscopy.

作者信息

Poppe L, Dabrowski J, von der Lieth C W, Koike K, Ogawa T

机构信息

Max-Planck-Institut für Medizinische Forschung, Heidelberg, Federal Republic of Germany.

出版信息

Eur J Biochem. 1990 Apr 30;189(2):313-25. doi: 10.1111/j.1432-1033.1990.tb15492.x.

DOI:10.1111/j.1432-1033.1990.tb15492.x
PMID:2159880
Abstract

Spatial structures of the oligosaccharide parts of globotriaosylceramide, Gal(alpha 1-4)Gal(beta 1-4)Glc(beta 1-1)Cer (Cer = ceramide) and isoglobotriaosylceramide, Gal(alpha 1-3)Gal(beta 1-4)Glc(beta 1-1)Cer were investigated in (C2H3)2SO solution by means of laboratory and rotating frame NOE, hydroxyl protons being used as long-range sensors defining the distance constraints. Both oligosaccharides were found to exist in more than one conformation interconverting rapidly on the NMR time scale. The conformation of the Gal(alpha 1-4)Gal(beta 1-4)Glc beta trisaccharide dissolved in 2H2O appeared to be the same as that of the corresponding part of the glycosphingolipid in (C2H3)2SO solution.

摘要

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