ThoraxCentre, Erasmus Medical Center, Rotterdam, The Netherlands; The Emergency & Critical Care Center of Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China.
ThoraxCentre, Erasmus Medical Center, Rotterdam, The Netherlands.
Atherosclerosis. 2018 Feb;269:6-13. doi: 10.1016/j.atherosclerosis.2017.11.002. Epub 2017 Dec 2.
Whether coronary calcification is correlated with plaque/media shrinkage (PS) remains unclear. The aim of this study was to assess the relationship between the calcification process and PS, combining serial optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in vessels treated with bioresorbable vascular scaffolds (BVS).
In 15 patients (16 vessels), OCT and IVUS images were matched using anatomic landmarks at post-procedure and five years. PS was defined as relative decrease in plaque/media area >5%. The association between the calcification process and PS was investigated. Mixed effect models were used to assess correlations and changes over time.
Seventy-two OCT and IVUS paired cross sections in- and out-scaffolded segments were matched at baseline and follow-up (432 images). In total, 35 out of the 72 cross sections showed PS, and 37 cross sections showed no PS (non-PS) at 5-year follow-up. Delta (Δ) plaque/media area showed negative correlation with Δ OCT calcium area (r = -0.29, p = 0.004), Δ OCT calcium arc (r = -0.42, p < 0.001), Δ OCT calcium length (r = -0.5, p < 0.001), and Δ IVUS calcium arc (r = -0.31, p = 0.024), respectively. On echogenicity analysis, Δ plaque/media area was positively associated with Δ hypoechogenic area (r = 0.47, p = 0.002). An increase in calcium area was negatively correlated to Δ hypoechogenicity (r = -0.29, p < 0.016). The increase in calcium area was positively correlated with Δ lumen area (r = 0.24, p = 0.044).
In segments treated with BVS, the calcification process was associated with PS, decrease in the hypoechogenic tissue and late luminal enlargement. Combining IVUS and OCT provides a unique method to assess the correlation between the calcification process and plaque/media shrinkage.
冠状动脉钙化与斑块/中膜收缩（PS）是否相关尚不清楚。本研究旨在评估生物可吸收支架（BVS）治疗后，通过连续光学相干断层扫描（OCT）和血管内超声（IVUS）评估钙化过程与 PS 的关系。
15 名患者（16 支血管），在术后即刻和 5 年时通过解剖学标志对 OCT 和 IVUS 图像进行匹配。PS 定义为斑块/中膜面积相对减少>5%。研究钙化过程与 PS 的关系。采用混合效应模型评估相关性和随时间的变化。
在基线和随访时匹配了 72 个 OCT 和 IVUS 配对的血管内支架段和支架外段的横截面（432 个图像）。总共 72 个横截面中有 35 个在 5 年随访时出现 PS，37 个横截面无 PS（非 PS）。Δ斑块/中膜面积与 ΔOCT 钙面积（r=-0.29，p=0.004）、ΔOCT 钙弧（r=-0.42，p<0.001）、ΔOCT 钙长度（r=-0.5，p<0.001）和 ΔIVUS 钙弧（r=-0.31，p=0.024）呈负相关。在回声分析中，Δ斑块/中膜面积与 Δ低回声面积呈正相关（r=0.47，p=0.002）。钙面积增加与 Δ低回声性呈负相关（r=-0.29，p<0.016）。钙面积增加与 Δ管腔面积呈正相关（r=0.24，p=0.044）。
在 BVS 治疗的节段中，钙化过程与 PS、低回声组织减少和晚期管腔扩大相关。结合 IVUS 和 OCT 提供了一种独特的方法来评估钙化过程与斑块/中膜收缩之间的相关性。
