肉瘤中染色体易位和融合基因的研究进展及其潜在的治疗应用。
Advances in chromosomal translocations and fusion genes in sarcomas and potential therapeutic applications.
机构信息
Department of Orthopedics, Xijing Hospital, Forth Military Medical University, Xian 710032, Shaanxi, PR China; Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles E. Young. Dr. South, Los Angeles, CA 90095-6902, USA.
Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, USA.
出版信息
Cancer Treat Rev. 2018 Feb;63:61-70. doi: 10.1016/j.ctrv.2017.12.001. Epub 2017 Dec 6.
Chromosomal translocations and fusion genes are very common in human cancer especially in subtypes of sarcomas, such as rhabdomyosarcoma, Ewing's sarcoma, synovial sarcoma and liposarcoma. The discovery of novel chromosomal translocations and fusion genes in different tumors are due to the advancement of next-generation sequencing (NGS) technologies such as whole genome sequencing. Recently, many novel chromosomal translocations and gene fusions have been identified in different types of sarcoma through NGS approaches. In addition to previously known sarcoma fusion genes, these novel specific fusion genes and associated molecular events represent important targets for novel therapeutic approaches in the treatment of sarcomas. This review focuses on recent advances in chromosomal translocations and fusion genes in sarcomas and their potential therapeutic applications in the treatment of sarcomas.
染色体易位和融合基因在人类癌症中非常常见，尤其是在肉瘤的亚型中，如横纹肌肉瘤、尤文肉瘤、滑膜肉瘤和脂肪肉瘤。新型染色体易位和融合基因在不同肿瘤中的发现，是由于下一代测序（NGS）技术的进步，如全基因组测序。最近，通过 NGS 方法，在不同类型的肉瘤中已经鉴定出许多新型染色体易位和基因融合。除了先前已知的肉瘤融合基因外，这些新型的特异性融合基因和相关的分子事件代表了治疗肉瘤的新型治疗方法的重要靶点。这篇综述主要关注肉瘤中染色体易位和融合基因的最新进展及其在肉瘤治疗中的潜在治疗应用。
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