Fletcher J A
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Curr Opin Oncol. 1994 Jul;6(4):367-71. doi: 10.1097/00001622-199407000-00008.
Many sarcomas contain characteristic chromosome translocations that result in the fusion of genes from two different chromosomes. This review focuses on the translocated genes that have been identified recently in Ewing's sarcoma, peripheral primitive neuroectodermal tumor, clear cell sarcoma, alveolar rhabdomyosarcoma, and myxoid liposarcoma. Each of these fusion genes encodes a DNA transcription factor that presumably regulates the function of other genes. Thus, a common mechanism of oncogenesis has been defined in histologically disparate varieties of sarcoma.
许多肉瘤含有特征性的染色体易位，导致来自两条不同染色体的基因融合。本综述聚焦于最近在尤因肉瘤、外周原始神经外胚层肿瘤、透明细胞肉瘤、肺泡状横纹肌肉瘤和黏液样脂肪肉瘤中鉴定出的易位基因。这些融合基因中的每一个都编码一种DNA转录因子，推测该转录因子可调节其他基因的功能。因此，在组织学上不同类型的肉瘤中已经确定了一种共同的肿瘤发生机制。
