Matsumoto N, Sato T, Suzuki T A
Department of Oral Physiology, School of Dentistry, Iwate Medical University, Japan.
Exp Brain Res. 1989;74(2):263-71. doi: 10.1007/BF00248859.
The columnar arrangement of tooth pulp-driven (TPD) neurons in the first somatosensory cortex (SI) was studied by single unit analysis in the cat anesthetized with nitrous oxide and halothane. Tactile sensitive neurons in the oral area of SI were arranged functionally in a columnar organization. About 32% of the recorded neurons also responded to tooth pulp stimulation. Thus, the TPD neurons located in area 3b seem to be multireceptive in sensory modality. About 80% of the TPD neurons were F-type which respond with a short latency to tooth pulp stimulation and receive input from a small number of teeth. When a microelectrode penetrated through a single vertical column, most of the F-type TPD neurons encountered received common input from one or two tooth pulps. However, when an electrode was inserted across more than one column, there was no common pulpal input to the TPD neurons encountered in a track. Thus, the TPD neurons in a single column had identical peripheral and pulpal receptive fields, and the same latency of responses to tooth pulp stimulation. These characteristics would support the hypothesis that TPD (presumed nociceptive) neurons are arranged in a vertical column and it may be inferred that the columnar organization of TPD neurons in SI plays an important role in the sensory-discriminative aspects of pulpal pain.
通过对一氧化二氮和氟烷麻醉的猫进行单单位分析，研究了第一体感皮层（SI）中牙髓驱动（TPD）神经元的柱状排列。SI口腔区域的触觉敏感神经元在功能上呈柱状组织排列。约32%的记录神经元也对牙髓刺激有反应。因此，位于3b区的TPD神经元在感觉模式上似乎具有多感受性。约80%的TPD神经元为F型，对牙髓刺激反应潜伏期短，且接受少数牙齿的输入。当微电极穿透单个垂直柱时，所遇到的大多数F型TPD神经元接受来自一或两个牙髓的共同输入。然而，当电极插入超过一个柱时，在一个轨迹中所遇到的TPD神经元没有共同的牙髓输入。因此，单个柱中的TPD神经元具有相同的外周和牙髓感受野，以及对牙髓刺激相同的反应潜伏期。这些特征将支持以下假设，即TPD（推测为伤害性）神经元呈垂直柱排列，并且可以推断SI中TPD神经元的柱状组织在牙髓疼痛的感觉辨别方面起重要作用。
