Stoddard S L, Tyce G M, Ahlskog J E, Zinsmeister A R, Carmichael S W
Department of Anatomy, Indiana University School of Medicine, Fort Wayne 46805.
Exp Neurol. 1989 Apr;104(1):22-7. doi: 10.1016/0014-4886(89)90004-6.
Autopsy specimens of adrenal medullae from parkinsonian and nonparkinsonian patients were analyzed for free catecholamines by high-performance liquid chromatography with electrochemical detection. The total free catecholamine content (nanomoles free catecholamine per milligram protein) was significantly lower in the parkinsonian patients than in the control population when the values were corrected for age and time from death to organ harvest. It is not established whether this decreased catecholamine content in the adrenals of parkinsonian patients is a concomitant of the disease itself or whether it is secondary to drug therapies used to treat the symptoms of Parkinson's disease.
采用高效液相色谱-电化学检测法，对帕金森病患者和非帕金森病患者的肾上腺髓质尸检标本进行游离儿茶酚胺分析。在校正年龄及从死亡到获取器官的时间后，帕金森病患者的总游离儿茶酚胺含量（每毫克蛋白质中游离儿茶酚胺的纳摩尔数）显著低于对照组人群。目前尚不清楚帕金森病患者肾上腺中儿茶酚胺含量降低是该疾病本身的伴随现象，还是帕金森病症状治疗所用药物疗法的继发结果。
