Paolino Giovanni, Moliterni Elisa, Corsetti Paola, Didona Dario, Bottoni Ugo, Calvieri Stefano, Mattozzi Carlo
Clinic of Dermatology, Sapienza University, Rome, Italy.
Clinic of Dermatology, Sapienza University, Rome, Italy -
G Ital Dermatol Venereol. 2019 Feb;154(1):64-71. doi: 10.23736/S0392-0488.17.05801-1. Epub 2017 Dec 15.
Despite the presence of several studies in literature, the real connection between vitamin D serological levels, vitamin D receptor and melanoma remains unclear, probably because of the complex correlation between vitamin D and melanoma. Indeed, UV radiations are not reported as the main risk factor for melanoma in non-sun-exposed, while systemic immunosuppression, anatomical and physiological features may contribute to malignancy. Therefore, the correlation between melanoma cells in sun-exposed areas and vitamin D, as well as vitamin D receptor could be different from the one in melanoma of sun-shielded sites. These differences may also explain the controversial results reported in the literature regarding the correlation between melanoma and vitamin D, as well as the different outcomes in melanoma patients treated with vitamin D as adjuvant therapy. The aim of this review is to highlight the most recent findings about vitamin D and melanoma, focusing on the anatomic site of the primary tumor as well as on the possible therapeutic uses of vitamin D in melanoma patients.
尽管文献中有多项研究，但维生素D血清水平、维生素D受体与黑色素瘤之间的真正联系仍不清楚，这可能是由于维生素D与黑色素瘤之间存在复杂的相关性。事实上，在非阳光暴露部位，紫外线辐射并未被报道为黑色素瘤的主要危险因素，而全身免疫抑制、解剖和生理特征可能与恶性肿瘤有关。因此，阳光暴露部位的黑色素瘤细胞与维生素D以及维生素D受体之间的相关性可能与阳光遮蔽部位的黑色素瘤不同。这些差异也可能解释了文献中报道的关于黑色素瘤与维生素D相关性的争议性结果，以及维生素D作为辅助治疗用于黑色素瘤患者时的不同疗效。本综述的目的是强调关于维生素D与黑色素瘤的最新发现，重点关注原发性肿瘤的解剖部位以及维生素D在黑色素瘤患者中的可能治疗用途。
