Viguier M
Service de dermatologie, hôpital Robert-Debré, Reims, France.
Ann Dermatol Venereol. 2017 Dec;144 Suppl 4:IVS47-IVS53. doi: 10.1016/S0151-9638(17)31065-7.
On a therapeutic point of view, 2017 in dermatology could be summarized in one disease, one pathway and in one number : atopic dermatitis, JAK inhibitors and 23. 2017 will be the year of the first registration of a biologic treatment in atopic dermatitis, dupilumab, with numerous other drugs currently in development. JAK inhibitors show promising results in several difficult-to-treat conditions, such as alopecia areata, vitiligo or atopic dermatitis, but still warrant confirmation in upcoming controlled trials. Monoclonal antibodies targeting IL-23 have confirmed in phase III studies their great efficacy in controlling psoriasis and will be soon available in practice, illustrating well the optimal link between bench side and bed in this emblematic inflammatory dermatological condition.
从治疗角度来看,2017年的皮肤病学可用一种疾病、一条通路和一个数字来概括:特应性皮炎、JAK抑制剂和23。2017年将是特应性皮炎生物治疗药物度普利尤单抗首次获批上市的一年,目前还有许多其他药物正在研发中。JAK抑制剂在斑秃、白癜风或特应性皮炎等几种难治性疾病中显示出了有前景的结果,但仍需在即将进行的对照试验中得到证实。靶向IL-23的单克隆抗体在III期研究中已证实其在控制银屑病方面具有显著疗效,并且很快将在临床应用,这很好地说明了在这种典型的炎症性皮肤病中实验室研究与临床实践之间的完美联系。