Wang Dongxin, Liu Xuejun, Zhou Bin, Kuang Weiping, Guo Tiansheng
Mental Health Institute of Hunan Province, The Brain Hospital of Hunan Province, Changsha, Hunan 410007, P.R. China.
Surgery Department of Mental Disease, The Brain Hospital of Hunan Province, Changsha, Hunan 410007, P.R. China.
Exp Ther Med. 2018 Jan;15(1):3-12. doi: 10.3892/etm.2017.5366. Epub 2017 Oct 24.
Deep brain stimulation is a method that involves using an electric stimulus on a specific target in the brain with stereotaxis. It is a minimally invasive, safe, adjustable and reversible nerve involvement technology. At present, this technique is widely applied to treat movement disorders and has produced promising effects on mental symptoms, including combined anxiety and depression. Deep brain stimulation has therefore been employed as a novel treatment for depression, obsessive-compulsive disorder, habituation, Tourette's syndrome, presenile dementia, anorexia nervosa and other refractory mental illnesses. Many encouraging results have been reported. The aim of the present review was to briefly describe the mechanisms, target selection, side effects, ethical arguments and risks associated with deep brain stimulation. Although deep brain stimulation is a developing and promising treatment, a large amount of research is still required to determine its curative effect, and the selection of patients and targets must be subjected to strict ethical standards.
深部脑刺激是一种通过立体定向对大脑特定靶点施加电刺激的方法。它是一种微创、安全、可调节且可逆的神经介入技术。目前，该技术广泛应用于治疗运动障碍，并且对包括焦虑和抑郁合并症在内的精神症状产生了有前景的效果。因此，深部脑刺激已被用作治疗抑郁症、强迫症、成瘾、抽动秽语综合征、早老性痴呆、神经性厌食症及其他难治性精神疾病的一种新疗法。已有许多令人鼓舞的结果报道。本综述的目的是简要描述与深部脑刺激相关的机制、靶点选择、副作用、伦理争议及风险。尽管深部脑刺激是一种不断发展且有前景的治疗方法，但仍需要大量研究来确定其疗效，并且患者和靶点的选择必须遵循严格的伦理标准。
