Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University Graduate School of Chemical Sciences and Engineering, Sapporo, 060-0815, Japan.
Dev Growth Differ. 2018 Jan;60(1):14-20. doi: 10.1111/dgd.12415. Epub 2017 Dec 18.
In multicellular organisms, incidentally emerging suboptimal cells are removed to maintain homeostasis of tissues. The unfavorable cells are excluded by a process termed cell competition whereby the resident normal cells actively eliminate the unfit cells of the identical lineage. Although the phenomenon of cell competition was originally discovered in Drosophila, a number of recent studies have provided implications of cell competition in tissue regeneration, development and oncogenesis in mammals. Here the roles of cell competition in fly to mammals are discussed.
在多细胞生物中，偶然出现的次优细胞会被清除，以维持组织的内稳态。通过一种称为细胞竞争的过程来排除不利细胞，其中驻留的正常细胞主动消除同系的不适宜细胞。尽管细胞竞争现象最初是在果蝇中发现的，但最近的许多研究都表明细胞竞争在哺乳动物的组织再生、发育和肿瘤发生中具有重要意义。本文讨论了细胞竞争在果蝇到哺乳动物中的作用。
