Brachial Plexopathy Following Use of Recombinant Human BMP-2 for Treatment of Atrophic Delayed Union of the Clavicle.
作者信息
Matthews John R, Margolis David S, Wu Eileen, Truchan Lisa M
机构信息
College of Medicine - Tucson, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724.
Department of Orthopaedic Surgery, University of Arizona, 1609 North Warren Avenue, Room 108, Tucson, AZ 85719.
出版信息
JBJS Case Connect. 2015 Sep 23;5(3):e81. doi: 10.2106/JBJS.CC.N.00187.
CASE
Although recombinant human bone morphogenetic protein-2 (rhBMP-2) is approved for treatment of open tibial fractures and anterior lumbar interbody fusion, off-label use has been associated with complications such as local inflammation, osteolysis, and dysphagia. This case report describes a patient treated with rhBMP-2 for an atrophic delayed union of a clavicular fracture who subsequently developed a profound motor and sensory brachial plexopathy.
CONCLUSION
Use of rhBMP-2 near peripheral nerves may cause neuropathy. This should be considered prior to its use in surgical sites with peripheral nerves in proximity.
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