Kobashi Hidenaga, Kamiya Kazutaka, Shimizu Kimiya
Department of Ophthalmology University of Kitasato School of Medicine Kanagawa, Japan.
Optom Vis Sci. 2018 Jan;95(1):21-26. doi: 10.1097/OPX.0000000000001157.
In eyes with mild Fuchs' endothelial corneal dystrophy without significant corneal edema, objective scattering index has the strongest influence on distance visual acuity, followed by the anterior corneal densitometry. Our findings suggest that distance visual acuity deteriorates in eyes with higher forward light scatter.
To evaluate the factors affecting distance visual acuity in patients with Fuchs' endothelial corneal dystrophy.
This retrospective study comprised 31 eyes of 31 patients with mild Fuchs' dystrophy without corneal edema and 25 eyes of 25 age-matched healthy subjects. Stepwise multiple regression analysis was used to assess the relationship between distance acuity with age, sex, forward light scatter, corneal backward scatter, anterior and posterior corneal higher-order aberrations, endothelial cell density, central corneal thickness, and corneal astigmatism.
The forward light scatter, corneal backward scatter, and corneal higher-order aberrations were significantly larger in the Fuchs' dystrophy group than those in the control group (P ≤ .004). In a univariate analysis, with higher forward light scatter, anterior corneal backward scatter, corneal higher-order aberrations, and age, the distance acuity significantly deteriorated in eyes with Fuchs' dystrophy. In a multiple linear regression analysis, explanatory variables relevant to the distance acuity were the forward light scatter (P < .001, partial regression coefficient B = 0.035) and anterior corneal backward scatter (P = 0.2, B = 0.008) (adjusted R = 0.694).
Eyes with higher light scatter, especially forward light scattering, showed deteriorated visual acuity. Results suggest that forward light scatter and corneal backward scatter play a more important role in visual performance than corneal higher-order aberrations in Fuchs' endothelial corneal dystrophy.
在没有明显角膜水肿的轻度富克斯内皮角膜营养不良眼中，客观散射指数对远视力的影响最强，其次是角膜前密度测量。我们的研究结果表明，前向光散射较高的眼睛远视力会下降。
评估影响富克斯内皮角膜营养不良患者远视力的因素。
这项回顾性研究包括31例无角膜水肿的轻度富克斯营养不良患者的31只眼和25例年龄匹配的健康受试者的25只眼。采用逐步多元回归分析评估远视力与年龄、性别、前向光散射、角膜后向散射、角膜前后高阶像差、内皮细胞密度、中央角膜厚度和角膜散光之间的关系。
富克斯营养不良组的前向光散射、角膜后向散射和角膜高阶像差明显大于对照组（P≤0.004）。在单因素分析中，随着前向光散射、角膜前向散射、角膜高阶像差和年龄的增加，富克斯营养不良患者的远视力显著下降。在多元线性回归分析中，与远视力相关的解释变量是前向光散射（P<0.001，偏回归系数B = 0.035）和角膜前向散射（P = 0.2，B = 0.008）（调整后R = 0.694）。
光散射较高的眼睛，尤其是前向光散射，视力会下降。结果表明，在富克斯内皮角膜营养不良中，前向光散射和角膜后向散射在视觉表现中比角膜高阶像差起更重要的作用。
