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带瓣主动脉-二尖瓣同种异体移植治疗双瓣心内膜炎:“半突击队”手术。早期和中期结果。

The incorporated aortomitral homograft for double-valve endocarditis: the 'hemi-Commando' procedure. Early and mid-term outcomes.

机构信息

Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.

Case Western Reserve University, School of Medicine, Cleveland, OH, USA.

出版信息

Eur J Cardiothorac Surg. 2018 May 1;53(5):1055-1061. doi: 10.1093/ejcts/ezx439.

Abstract

OBJECTIVES

Surgical management of invasive double-valve infective endocarditis (IE) involving the intervalvular fibrosa (IVF) is a technical challenge that requires extensive debridement followed by complex reconstruction. In this study, we present the early and mid-term outcomes of the hemi-Commando procedure and aortic root replacement with reconstruction of IVF using an aortomitral allograft.

METHODS

From 2010 to 2017, 37 patients with IE involving the IVF underwent the hemi-Commando procedure. Postoperative clinical data and echocardiograms were reviewed for the assessment of cardiac structural integrity and clinical outcomes.

RESULTS

Twenty-nine (78%) cases were redo surgery and 15 (41%) were emergency surgery. Preoperatively, 70% (n = 26) of patients were admitted to the intensive care unit and 11% (n = 4) of patients were in septic shock. Ten (27%) patients had native aortic valve IE, while 27 (73%) patients had prosthetic valve IE. Hospital death occurred in 8% (n = 3) of patients due to multisystem organ failure. Postoperative echocardiogram showed no aortic regurgitation in 86% (n = 32) and mild regurgitation in 14% (n = 5) of patients, while mitral regurgitation prevalence was none/trivial in 62% (n = 23), mild in 32% (n = 12) and moderate in 5%. Intact IVF reconstruction was confirmed in all patients with no abnormal communication between the left heart chambers. One-year survival was 91%, while 3-year survival was 82%. Mid-term follow up revealed 1 death secondary to recurrent IE.

CONCLUSIONS

Compared to double-valve replacement with IVF reconstruction ('Commando operation'), the early and mid-term outcomes of the hemi-Commando procedure proved to be a feasible treatment option for IVF reconstruction, enabling preservation of the mitral valve and the subvalvular apparatus in high-risk patients with invasive double-valve IE.

摘要

目的

涉及瓣下纤维间隔(IVF)的侵袭性双瓣心内膜炎(IE)的手术治疗是一项技术挑战,需要广泛清创,然后进行复杂的重建。在本研究中,我们报告了使用同种异体主动脉二尖瓣瓣环重建行半康曼多手术和主动脉根部置换治疗 IVF 感染性心内膜炎的早期和中期结果。

方法

2010 年至 2017 年,37 例 IVF 受累的 IE 患者接受了半康曼多手术。回顾术后临床资料和超声心动图,评估心脏结构完整性和临床结果。

结果

29 例(78%)为再次手术,15 例(41%)为急诊手术。术前,70%(n=26)的患者入住重症监护病房,11%(n=4)的患者出现感染性休克。10 例(27%)患者为自体主动脉瓣 IE,27 例(73%)患者为人工瓣膜 IE。8%(n=3)的患者因多器官功能衰竭死亡。术后超声心动图显示 86%(n=32)的患者无主动脉瓣反流,14%(n=5)的患者轻度反流,62%(n=23)的患者二尖瓣反流程度为无/轻微,32%(n=12)为轻度,5%为中度。所有患者 IVF 重建完整,左心腔之间无异常交通。1 年生存率为 91%,3 年生存率为 82%。中期随访发现 1 例因复发性 IE 死亡。

结论

与双瓣置换加 IVF 重建(“康曼多手术”)相比,半康曼多手术的早期和中期结果证明是一种可行的治疗选择,可在高危侵袭性双瓣 IE 患者中保留二尖瓣和瓣下结构。

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