McFadzean R M, Graham D I, Lee W R, Mendelow A D
Department of Neuro-ophthalmology, Institute of Neurological Sciences, Glasgow, Scotland.
Invest Ophthalmol Vis Sci. 1989 Mar;30(3):487-90.
Ocular blood flow was measured in the juxtapapillary choroid, retrolaminar optic nerve and ciliary body mesoderm using 14C-labelled iodoantipyrine with quantitative autoradiography in seven anesthetized baboons in an experimental model of cerebral and ocular ischemia induced by hemorrhagic hypotension following unilateral common carotid stenosis, with external carotid ligation. The eyes of seven baboons with unilateral common carotid occlusion were also examined histologically for evidence of structural changes. This autoradiographic method allowed measurement of blood flow in different ocular structures and a significant change was noted in the optic nerve of stenosed animals, without structural damage.
在一个实验模型中，对七只麻醉的狒狒进行研究。该模型通过单侧颈总动脉狭窄并结扎颈外动脉，造成出血性低血压，从而引发脑和眼部缺血。使用¹⁴C标记的碘安替比林和定量放射自显影技术，测量了视乳头旁脉络膜、视神经管后段视神经以及睫状体中胚层的眼部血流。还对七只单侧颈总动脉闭塞的狒狒的眼睛进行了组织学检查，以寻找结构变化的证据。这种放射自显影方法能够测量不同眼部结构的血流，并且在狭窄动物的视神经中观察到了显著变化，而没有结构损伤。
