Couch J R, Hassanein R S
Headache. 1989 Jan;29(1):49-54. doi: 10.1111/j.1526-4610.1989.hed2901049.x.
A group of 350 migraineurs (87 male, 263 female) and 300 controls without migraine (104 male, 196 female) were questioned about occurrence, in parents, of the atherosclerosis-related diseases (ASRD) of diabetes mellitus (DM), hypertension (HBP), myocardial infarction (MI), and stroke as well as about recurrent severe headache (RSHA). Occurrence of DM, HBP, MI and stroke was compared for mothers and fathers of migraine vs. those of control subjects and no significant differences were found. The mothers and fathers were pooled and resegregated by presence or absence of RSHA and then occurrence of DM, HBP, MI and stroke again compared. For mothers there was increased occurrence of stroke and DM in the RSHA group but the differences were not significant. For RSHA fathers there was increased incidence of MI (p less than .10) and HBP (p less than .01). Aggregate occurrence of all ASRD was evaluated for RSHA vs. no-RSHA parents. ASRD occurred more frequently in the RSHA than in the no-RSHA parents (p less than .05). Breakdown by age showed that this occurred at all ages in men (p less than .05) but in women the difference was significant only under age 60 (p less than .05). This study suggests that RSHA, which is primarily migraine, may be a risk factor or a marker for occurrence of ASRD.
对350名偏头痛患者（87名男性，263名女性）和300名无偏头痛的对照者（104名男性，196名女性）进行了询问，了解其父母中糖尿病（DM）、高血压（HBP）、心肌梗死（MI）和中风等动脉粥样硬化相关疾病（ASRD）的发生情况以及复发性严重头痛（RSHA）的情况。比较了偏头痛患者与对照者的父母中DM、HBP、MI和中风的发生率，未发现显著差异。将父母合并，并根据是否存在RSHA重新分类，然后再次比较DM、HBP、MI和中风的发生率。对于母亲，RSHA组中风和DM的发生率有所增加，但差异不显著。对于有RSHA的父亲，MI（p<0.10）和HBP（p<0.01）的发生率增加。评估了有RSHA与无RSHA的父母中所有ASRD的总发生率。ASRD在有RSHA的父母中比在无RSHA的父母中更频繁发生（p<0.05）。按年龄细分显示，男性在所有年龄段均如此（p<0.05），但女性仅在60岁以下差异显著（p<0.05）。这项研究表明，主要为偏头痛的RSHA可能是ASRD发生的危险因素或标志物。
