Odum Ehimen Phyllis, Young Ekenechukwu Esther
Department of Chemical Pathology, University of Port Harcourt Teaching Hospital Port Harcourt, Rivers State, Nigeria.
Department of Medicine, University of Nigeria, Ituku/Ozalla, Enugu State, Nigeria.
Diabetes Metab Syndr. 2018 Apr-Jun;12(2):141-145. doi: 10.1016/j.dsx.2017.12.001. Epub 2017 Dec 14.
Elevated cardiac troponin I, Creatine kinase (CK-MB) and Myoglobin levels are observed in the setting of acute myocardial damage. However sub-clinical elevations occur in patients with diabetes mellitus. This study was carried out to determine the relationship between the presence of multiple cardiovascular risk factors and the metabolic syndrome and elevations in cardiac markers in patients with type2 diabetes mellitus.
Consecutive stable out-patients with type2 diabetes mellitus at the University of Port Harcourt Teaching Hospital, Nigeria were recruited. Non-diabetic individuals such as hospital staff and the general public acted as controls. Baseline demographic data collection was done and waist circumference, weight, height and blood pressure were measured. Venous samples were assayed for CTnI, CK-MB and Myoglobin levels using ELISA. Data was analysed using SPSS v 20.
There were 188 DM patients, who were older than the 200 control subjects (56.1 ± 13.1 years and 42.7 ± 5.7 years, p < 0.001). Mean duration of diabetes was 7.1(5.7) years. Hypertension was present in 59%, 84.6% had dyslipidaemia, while 76.1% had metabolic syndrome. All the cardiac markers were significantly higher in DM patients than controls. The presence of hypertension or dyslipidaemia was not significantly associated with the cardiac markers (p > 0.05 for all), however the DM patients with metabolic syndrome had higher levels of CK-MB and myoglobin but not CTnI than those without.
Diabetes mellitus is associated with chronic sub-clinical elevation of cardiac markers and this is more in those with multiple cardiovascular risk factors and/or the metabolic syndrome.
在急性心肌损伤时可观察到心肌肌钙蛋白I、肌酸激酶（CK-MB）和肌红蛋白水平升高。然而，糖尿病患者会出现亚临床水平升高。本研究旨在确定2型糖尿病患者多种心血管危险因素和代谢综合征的存在与心脏标志物升高之间的关系。
招募了尼日利亚哈科特港大学教学医院连续的2型糖尿病稳定门诊患者。医院工作人员和普通公众等非糖尿病个体作为对照。收集基线人口统计学数据，并测量腰围、体重、身高和血压。使用酶联免疫吸附测定法（ELISA）检测静脉样本中的肌钙蛋白I（CTnI）、CK-MB和肌红蛋白水平。使用SPSS v 20软件进行数据分析。
有188名糖尿病患者，他们比200名对照对象年龄更大（分别为56.1±13.1岁和42.7±5.7岁，p<0.001）。糖尿病平均病程为7.1（5.7）年。59%的患者患有高血压，84.6%的患者有血脂异常，而76.1%的患者有代谢综合征。所有心脏标志物在糖尿病患者中均显著高于对照组。高血压或血脂异常的存在与心脏标志物无显著相关性（所有p>0.05），然而，患有代谢综合征的糖尿病患者的CK-MB和肌红蛋白水平高于无代谢综合征的患者，但肌钙蛋白I水平并非如此。
糖尿病与心脏标志物的慢性亚临床升高有关，在具有多种心血管危险因素和/或代谢综合征的患者中更为明显。
