Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.
Department of Neurology, University Hospital of North Norway, Tromsø, Norway.
PLoS One. 2023 Feb 2;18(2):e0281239. doi: 10.1371/journal.pone.0281239. eCollection 2023.
Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nondiabetic general population.
Associations between CK and the outcome variable HbA1C (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA1C (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway.
Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA1C (%) in the "high CK" group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the "normal CK" group, P <0.001. CK increased significantly and linearly with higher levels of HbA1C (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA1C (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA1C (%).
These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population.
肌酸激酶（CK）与胰岛素抵抗有关，并且被认为是心血管疾病的风险标志物，主要是因为它与高血压和体重指数增加有关。本研究旨在确定 CK 是否可预测非糖尿病人群中的糖化血红蛋白（HbA1C）。
在挪威特罗姆瑟研究（Tromsø 6）中，对 11662 名 HbA1C（%）<6.5 的非糖尿病参与者进行方差和多元分析，以确定 CK 与结局变量 HbA1C（%）之间的关系。
在 11662 名参与者中，有 543 名（4.66%）检测到异常升高的 CK。“高 CK”组的平均 HbA1C（%）为 5.62（SD = 0.33），而“正常 CK”组为 5.52（SD = 0.36），P<0.001。在女性中，CK 随着 HbA1C（%）四分位数的升高而显著呈线性增加（P<0.001），在男性中呈非线性增加（P<0.001）。在多元分析中，CK 在调整年龄、性别、体重指数、血压、血糖、血脂、C 反应蛋白、肌酐、丙氨酸氨基转移酶和天冬氨酸氨基转移酶后，与 HbA1C（%）独立相关。CK 的自然对数值每增加 1 单位，HbA1C 就会增加 0.17 单位（%）。
这些数据表明，在非糖尿病普通人群中，CK 与糖化血红蛋白呈正相关且独立相关。
