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心力衰竭中肌腱蛋白-C与N末端B型利钠肽原水平及心律失常患病率之间的关联。

Association among tenascin-C and NT-proBNP levels and arrhythmia prevalence in heart failure.

作者信息

Ozmen Caglar, Deniz Ali, Deveci Onur S, Cagliyan Caglar E, Celik Aziz I, Yildiz İbrahim, Yildiz Pinar Ö, Demir Mesut, Kanadasi Mehmet

机构信息

Kahramanmaras Pazarc?k State Hospital, Department of Cardiology, .

出版信息

Clin Invest Med. 2017 Dec 17;40(6):E219-E227. doi: 10.25011/cim.v40i6.29122.

DOI:10.25011/cim.v40i6.29122
PMID:29256387
Abstract

PURPOSE

Tenascin-C (TN-C) and amino-terminal fragment of the B-type natriuretic peptide (NT-proBNP) are the important predictors in prognosis of heart failure (HF). The aim of this study was to analyze the relationship of TN-C and NT-proBNP levels with the frequency and severity of ventricular arrhythmia.

MATERIALS AND METHODS

Our study included 107 HF patients with EF < 45%. According to Holter analysis, the patients were divided into two groups as malignant arrhythmia group (n=29) with Lown Class 4a and 4b arrhythmia and benign arrhythmia group(n=78) with Lown Class 0-3b arrhythmia. The groups were compared with respect to levels of TN-C and NT-proBNP. The relationship of TN-C and NT-proBNP levels with frequency of ventricular premature beat (VPB) was also analyzed.

FINDINGS

NT-proBNP (5042.1±1626 versus 1417.1±1711.6 pg/ml) and TN-C (1089±348.6 versus 758.5±423.9 ng/ml) levels were significantly higher in the malignant arrhythmia group than that of the benign arrhythmia group (p.

摘要

目的

腱生蛋白-C(TN-C)和B型利钠肽氨基末端片段(NT-proBNP)是心力衰竭(HF)预后的重要预测指标。本研究旨在分析TN-C和NT-proBNP水平与室性心律失常的频率和严重程度之间的关系。

材料与方法

我们的研究纳入了107例射血分数(EF)<45%的HF患者。根据动态心电图分析,将患者分为两组,即伴有洛恩4a级和4b级心律失常的恶性心律失常组(n = 29)和伴有洛恩0-3b级心律失常的良性心律失常组(n = 78)。比较两组患者的TN-C和NT-proBNP水平。还分析了TN-C和NT-proBNP水平与室性早搏(VPB)频率的关系。

研究结果

恶性心律失常组的NT-proBNP水平(5042.1±1626对1417.1±1711.6 pg/ml)和TN-C水平(1089±348.6对758.5±423.9 ng/ml)显著高于良性心律失常组(p......(原文此处不完整)

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