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日本低风险手术前的术前血液检查:一项使用全国保险索赔数据库的回顾性观察研究。

Preoperative Blood Tests Conducted Before Low-Risk Surgery in Japan: A Retrospective Observational Study Using a Nationwide Insurance Claims Database.

机构信息

Clinical Biostatistics.

Anesthesia, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

出版信息

Anesth Analg. 2018 May;126(5):1633-1640. doi: 10.1213/ANE.0000000000002734.

Abstract

BACKGROUND

Routine preoperative testing is discouraged before low-risk surgery because testing does not provide any beneficial effect in terms of patient outcome. However, few studies have assessed the utilization of hospital health care resources in terms of preoperative tests in a real-world setting. Here, we aimed to assess the prevalence and factors associated with preoperative blood tests before low-risk surgery in Japan.

METHODS

In this retrospective observational study, we used the nationwide insurance claims data of Japan. Patients who underwent low-risk surgeries between April 1, 2012 and March 31, 2016, were included. Our primary outcome was the receipt of any preoperative tests within 60 days before an index procedure: complete blood count, basic metabolic panel, coagulation tests, and liver function tests. We performed a descriptive analysis to estimate the proportions of preoperative blood tests, and examined the associations between patient-level and institutional-level factors and preoperative blood tests, using multilevel logistic regression analysis. Interinstitutional variation in the utilization of preoperative tests was summarized using the median odds ratio (OR).

RESULTS

The study sample included 59,818 patients (mean [standard deviation] age, 44.0 [11.3] years; 33,574 [56.1%] women) from 9746 institutions. The overall proportion of each test was: complete blood count, 58.7%; metabolic panel, 47.8%; coagulation tests, 36.6%; and liver function tests, 48.5%. The proportion receiving any preoperative tests in the overall sample was 59.5%. Multilevel logistic regression analysis indicated that preoperative blood tests were associated with the Charlson comorbidity index score (score ≥3: adjusted OR, 4.21; 95% confidence interval [CI], 3.69-4.80), anticoagulant use (adjusted OR, 4.12; 95% CI, 2.35-7.22), type of anesthesia (general anesthesia: adjusted OR, 5.69; 95% CI, 4.85-6.68; regional anesthesia: adjusted OR, 3.76; 95% CI, 3.28-4.30), surgical setting (inpatient procedure: adjusted OR, 3.64; 95% CI, 3.30-4.00), and number of beds (≥100 beds: adjusted OR, 3.61; 95% CI, 3.19-4.08). The median institutional-specific proportion of preoperative tests was 40.0% (interquartile range, 0%-100%). The median OR for interinstitutional variation in ordering preoperative tests was 4.34. These findings were consistent across a sensitivity analysis.

CONCLUSIONS

Preoperative blood tests were performed before 59.5% of low-risk surgeries. Preoperative tests were associated with the type of anesthesia, patient characteristics, and medical facility status. There was a substantial interinstitutional variation in the utilization of preoperative tests.

摘要

背景

在低风险手术前不鼓励常规术前检查,因为检查在患者预后方面没有任何有益效果。然而,很少有研究在真实环境中评估术前检查在医院卫生保健资源利用方面的情况。在这里,我们旨在评估日本低风险手术前接受术前血液检查的流行率和相关因素。

方法

本回顾性观察性研究使用了日本全国性的保险索赔数据。纳入了 2012 年 4 月 1 日至 2016 年 3 月 31 日期间接受低风险手术的患者。我们的主要结局是在指数手术前 60 天内接受任何术前检查:全血细胞计数、基本代谢面板、凝血检查和肝功能检查。我们进行了描述性分析,以估计术前血液检查的比例,并使用多水平逻辑回归分析检查患者水平和机构水平因素与术前血液检查之间的关联。使用中位数优势比(OR)总结术前检查利用的机构间变异。

结果

研究样本包括来自 9746 家机构的 59818 名患者(平均[标准差]年龄 44.0[11.3]岁;33574[56.1%]名女性)。每种检查的总体比例为:全血细胞计数 58.7%;代谢面板 47.8%;凝血检查 36.6%;肝功能检查 48.5%。总体样本中接受任何术前检查的比例为 59.5%。多水平逻辑回归分析表明,术前血液检查与 Charlson 合并症指数评分(评分≥3:调整后的 OR,4.21;95%置信区间[CI],3.69-4.80)、抗凝药物使用(调整后的 OR,4.12;95% CI,2.35-7.22)、麻醉类型(全身麻醉:调整后的 OR,5.69;95% CI,4.85-6.68;区域麻醉:调整后的 OR,3.76;95% CI,3.28-4.30)、手术设置(住院手术:调整后的 OR,3.64;95% CI,3.30-4.00)和床位数量(≥100 张床位:调整后的 OR,3.61;95% CI,3.19-4.08)有关。术前检查机构特异性比例的中位数为 40.0%(四分位距,0%-100%)。机构间术前检查订单变异的中位数 OR 为 4.34。这些发现在敏感性分析中是一致的。

结论

术前血液检查在 59.5%的低风险手术前进行。术前检查与麻醉类型、患者特征和医疗机构状况有关。术前检查的利用存在很大的机构间差异。

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