具有抗疟活性的喹啉类杂合化合物。
Quinoline-Based Hybrid Compounds with Antimalarial Activity.
机构信息
Department of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa.
出版信息
Molecules. 2017 Dec 19;22(12):2268. doi: 10.3390/molecules22122268.
The application of quinoline-based compounds for the treatment of malaria infections is hampered by drug resistance. Drug resistance has led to the combination of quinolines with other classes of antimalarials resulting in enhanced therapeutic outcomes. However, the combination of antimalarials is limited by drug-drug interactions. In order to overcome the aforementioned factors, several researchers have reported hybrid compounds prepared by reacting quinoline-based compounds with other compounds via selected functionalities. This review will focus on the currently reported quinoline-based hybrid compounds and their preclinical studies.
喹啉类化合物在治疗疟疾感染方面的应用受到耐药性的阻碍。耐药性导致了喹啉类药物与其他类别的抗疟药物联合使用，从而提高了治疗效果。然而，抗疟药物的联合使用受到药物相互作用的限制。为了克服上述因素，一些研究人员已经报道了通过选择的官能团将基于喹啉的化合物与其他化合物反应制备的杂合化合物。本综述将重点介绍目前报道的基于喹啉的杂合化合物及其临床前研究。
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