Cook S D, Thomas K A, Kester M A
Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, LA 70112.
J Bone Joint Surg Br. 1989 Mar;71(2):189-97. doi: 10.1302/0301-620X.71B2.2925733.
We studied cartilage degeneration in 45 canine acetabula after implantation of prostheses with articulating surfaces of low-temperature isotropic (LTI) pyrolytic carbon, cobalt-chromium-molybdenum alloy and titanium alloy for periods ranging from two weeks to 18 months. Gross specimens and histological sections were compared with the nonoperated (control) acetabulum of the same animal. Cartilage articulating with LTI pyrolytic carbon exhibited significantly lower levels of gross wear, fibrillation, eburnation, glycosaminoglycan loss, and subchondral bone change than with metallic surfaces. Survivorship analysis showed a 92% probability of survival for cartilage articulating with LTI pyrolytic carbon at 18 months, as compared to only a 20% probability of survival for cartilage articulating with either of the metallic alloys.
我们研究了45个犬髋臼在植入具有低温各向同性(LTI)热解碳、钴铬钼合金和钛合金关节面的假体后长达两周至18个月的软骨退变情况。将大体标本和组织学切片与同一动物未手术(对照)的髋臼进行比较。与金属表面相比,与LTI热解碳关节的软骨在大体磨损、纤维化、骨质象牙化、糖胺聚糖丢失和软骨下骨改变方面的水平显著更低。生存分析显示,与LTI热解碳关节的软骨在18个月时的生存概率为92%,而与任一种金属合金关节的软骨的生存概率仅为20%。