Braun Joseph M, Gray Kimberly
Department of Epidemiology, Brown University, Providence, Rhode Island, United States of America.
National Institute of Environmental Health Sciences, Durham, North Carolina, United States of America.
PLoS Biol. 2017 Dec 19;15(12):e2002800. doi: 10.1371/journal.pbio.2002800. eCollection 2017 Dec.
Epidemiological studies play an important role in quantifying how early life environmental chemical exposures influence the risk of childhood diseases. These studies face at least four major challenges that can produce noise when trying to identify signals of associations between chemical exposure and childhood health. Challenges include accurately estimating chemical exposure, confounding from causes of both exposure and disease, identifying periods of heightened vulnerability to chemical exposures, and determining the effects of chemical mixtures. We provide recommendations that will aid in identifying these signals with more precision.
流行病学研究在量化早期生活环境化学物质暴露如何影响儿童疾病风险方面发挥着重要作用。这些研究面临至少四个主要挑战，在试图识别化学物质暴露与儿童健康之间的关联信号时可能会产生干扰。挑战包括准确估计化学物质暴露、暴露和疾病原因导致的混杂、识别对化学物质暴露易感性增加的时期，以及确定化学混合物的影响。我们提供了有助于更精确识别这些信号的建议。
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