Department of Immunology, University of Washington, Seattle, WA 98109, United States.
Department of Immunology, University of Washington, Seattle, WA 98109, United States.
Curr Opin Immunol. 2018 Apr;51:1-6. doi: 10.1016/j.coi.2017.12.006. Epub 2017 Dec 16.
Recent thymic emigrants (RTEs) are those peripheral T cells that have most recently completed thymic development and egress. Over the past decade, significant advances have been made in understanding the cell-extrinsic and cell-intrinsic requirements for RTE maturation to mature naïve (MN) T cells and in detailing the functional differences that characterize these two T cell populations. Much of this work has suggested that RTEs are hypo-functional versions of more mature T cells. However, recent evidence has indicated that rather than being defective T cells, RTEs are exquisitely adapted to their cellular niche. In this review, we argue that RTEs are not flawed mature T cells but are adapted to fill an underpopulated T cell compartment, while maintaining self tolerance and possessing the capacity to mount robust immune responses.
最近胸腺迁出细胞（RTEs）是那些最近完成胸腺发育和迁出的外周 T 细胞。在过去的十年中，人们在理解 RTE 成熟为成熟幼稚（MN）T 细胞的细胞外在和细胞内在要求方面取得了重大进展，并详细描述了这两种 T 细胞群体的特征性功能差异。这项工作的大部分表明，RTE 是更成熟 T 细胞的低功能版本。然而，最近的证据表明，RTE 不是有缺陷的 T 细胞，而是适应其细胞生态位。在这篇综述中，我们认为 RTE 不是有缺陷的成熟 T 细胞，而是适应填补一个人口不足的 T 细胞区室，同时保持自身耐受并具有产生强大免疫反应的能力。
