Ding Xue, Fan Leilei, Xu Liran, Ma Xiuxia, Meng Pengfei, Li Jie, Li Jiahe, Yue Jingyu
Department of Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People's Republic of China.
Department of Cardiovascular, The First People's Hospital of Zhengzhou, Zhengzhou, People's Republic of China.
Infect Drug Resist. 2024 Dec 25;17:5827-5838. doi: 10.2147/IDR.S497083. eCollection 2024.
Antiretroviral therapy can reduce human immunodeficiency virus (HIV) load to undetectable levels and restore CD4+ T cells to rebuild immune function in patients with HIV. However, some patients fail to achieve immune reconstitution despite treatment. Traditional Chinese medicine is an important branch of complementary and alternative medicine for the treatment of HIV infection, and a growing number of studies has demonstrated that traditional Chinese medicine can increase CD4+ T cell counts in patients, thereby promoting immune reconstitution, ameliorating symptoms and signs, and improving quality of life. Here, we review pathogenesis in immunological non-responders and research into their treatment with traditional Chinese medicine. Furthermore, we summarize potential future research directions, including elucidation of how traditional Chinese medicine can regulate CD4+ T cells to reduce opportunistic infections and improve quality of life in immunological non-responders.
抗逆转录病毒疗法可将人类免疫缺陷病毒（HIV）载量降低至检测不到的水平，并使CD4 + T细胞恢复，从而重建HIV患者的免疫功能。然而，尽管接受了治疗，仍有一些患者未能实现免疫重建。中医是治疗HIV感染的补充和替代医学的一个重要分支，越来越多的研究表明，中医可以增加患者的CD4 + T细胞计数，从而促进免疫重建，改善症状体征，并提高生活质量。在此，我们综述免疫无应答者的发病机制以及中医对其治疗的研究。此外，我们总结了未来潜在的研究方向，包括阐明中医如何调节CD4 + T细胞以减少免疫无应答者的机会性感染并提高生活质量。
