• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

全髋关节置换术老年与中年患者皮质醇水平及炎症反应的比较：一项前瞻性观察研究

Comparison of cortisol and inflammatory response between aged and middle-aged patients undergoing total hip arthroplasty: a prospective observational study.

作者信息

Zhong Jian, Si Hai-Bo, Zeng Yi, Yang Jing, Zhou Zong-Ke, Kang Peng-de, Pei Fu-Xing, Shen Bin

机构信息

Department of orthopaedics, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

出版信息

BMC Musculoskelet Disord. 2017 Dec 19;18(1):541. doi: 10.1186/s12891-017-1900-y.

DOI:10.1186/s12891-017-1900-y
PMID:29258488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5738105/
Abstract

BACKGROUND

To investigate the differences in the perioperative serum cortisol, C-reactive protein (CRP) and interleukin-6 (IL-6) levels between aged and middle-aged patients undergoing total hip arthroplasty (THA).

METHODS

Sixty patients (30 aged and 30 middle-aged) undergoing THA for osteoarthritis between August 2016 and January 2017 participated in this study. Blood samples were collected preoperatively and at 6 hours, 24 hours and 3 days after surgery to measure the cortisol, CRP and IL-6 concentrations. The clinical outcomes were assessed using the visual analogue scale (VAS) pain score and Harris hip score (HHS).

RESULTS

No significant differences were found between the two groups before the operation in the cortisol, IL-6 and CRP levels; the VAS score; or the HHS. Cortisol was significantly lower at 6 hours after surgery in the aged group than in the middle-aged group (P < 0.05). IL-6 at 6 and 24 hours after surgery, CRP at 3 days after surgery and the VAS score at 6 and 24 hours after surgery in the aged group were significantly higher than those in the middle-aged group (P < 0.05). In the aged group, weak correlations were found between the cortisol concentration 6 hours after THA and the IL-6 level 24 hours after THA (r = -0.37, P = 0.04) and between the IL-6 level 6 hours after THA and the VAS score 24 hours after THA (r = 0.42, P = 0.02).

CONCLUSION

Aged patients showed lower cortisol levels at 6 hours after surgery and higher IL-6 levels at 6 and 24 hours after surgery than middle-aged patients undergoing THA.

摘要

背景

探讨老年和中年患者行全髋关节置换术（THA）围手术期血清皮质醇、C反应蛋白（CRP）及白细胞介素-6（IL-6）水平的差异。

方法

选取2016年8月至2017年1月期间因骨关节炎行THA的60例患者（30例老年患者和30例中年患者）参与本研究。于术前及术后6小时、24小时和3天采集血样，测定皮质醇、CRP和IL-6浓度。采用视觉模拟评分法（VAS）疼痛评分和Harris髋关节评分（HHS）评估临床结局。

结果

两组患者术前皮质醇、IL-6和CRP水平、VAS评分及HHS均无显著差异。老年组术后6小时皮质醇水平显著低于中年组（P<0.05）。老年组术后6小时和24小时的IL-6、术后3天的CRP以及术后6小时和24小时的VAS评分均显著高于中年组（P<0.05）。在老年组中，THA术后6小时的皮质醇浓度与术后24小时的IL-6水平之间（r = -0.37，P = 0.04）以及THA术后6小时的IL-6水平与术后24小时的VAS评分之间（r = 0.42, P = 0.02）存在弱相关性。

结论

与行THA的中年患者相比，老年患者术后6小时皮质醇水平较低，术后6小时和24小时IL-6水平较高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6fb/5738105/1ef3d6235600/12891_2017_1900_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6fb/5738105/22e7ef5bcafa/12891_2017_1900_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6fb/5738105/9e76a5e1d972/12891_2017_1900_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6fb/5738105/e59a0b2a46e1/12891_2017_1900_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6fb/5738105/1ef3d6235600/12891_2017_1900_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6fb/5738105/22e7ef5bcafa/12891_2017_1900_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6fb/5738105/9e76a5e1d972/12891_2017_1900_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6fb/5738105/e59a0b2a46e1/12891_2017_1900_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6fb/5738105/1ef3d6235600/12891_2017_1900_Fig4_HTML.jpg

相似文献

1
Comparison of cortisol and inflammatory response between aged and middle-aged patients undergoing total hip arthroplasty: a prospective observational study.全髋关节置换术老年与中年患者皮质醇水平及炎症反应的比较：一项前瞻性观察研究
BMC Musculoskelet Disord. 2017 Dec 19;18(1):541. doi: 10.1186/s12891-017-1900-y.
2
Relationship between Inflammatory Response and Estimated Complication Rate after Total Hip Arthroplasty.全髋关节置换术后炎症反应与估计并发症发生率之间的关系。
Chin Med J (Engl). 2016 Nov 5;129(21):2546-2551. doi: 10.4103/0366-6999.192772.
3
Effects of surgery start time on postoperative cortisol, inflammatory cytokines, and postoperative hospital day in hip surgery: Randomized controlled trial.髋关节手术中手术开始时间对术后皮质醇、炎症细胞因子及术后住院天数的影响：随机对照试验
Medicine (Baltimore). 2019 Jun;98(24):e15820. doi: 10.1097/MD.0000000000015820.
4
[COMPARISON OF PERIOPERATIVE INFLAMMATORY MARKERS BETWEEN PATIENTS WITH ANKYLOSING SPONDYLITIS AND NON-INFLAMMATORY DISEASES UNDERGOING TOTAL HIP ARTHROPLASTY].强直性脊柱炎患者与接受全髋关节置换术的非炎性疾病患者围手术期炎症标志物的比较
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015 Oct;29(10):1199-203.
5
Comparison of supercapsular percutaneously assisted approach total hip versus conventional posterior approach for total hip arthroplasty: a prospective, randomized controlled trial.经皮辅助囊上入路全髋关节置换术与传统后入路全髋关节置换术的比较：一项前瞻性随机对照试验。
J Orthop Surg Res. 2017 Sep 25;12(1):138. doi: 10.1186/s13018-017-0636-6.
6
[Effect of indwelling drainage tube and extubation time on recessive hemorrhage and functional recovery after total hip arthroplasty].[留置引流管及拔管时间对全髋关节置换术后隐性出血及功能恢复的影响]
Zhongguo Gu Shang. 2020 Aug 25;33(8):716-20. doi: 10.12200/j.issn.1003-0034.2020.08.006.
7
Multiple boluses of intravenous tranexamic acid to reduce hidden blood loss and the inflammatory response following enhanced-recovery primary total hip arthroplasty: a randomised clinical trial.多次静脉注射氨甲环酸以减少加速康复初次全髋关节置换术后的隐性失血和炎症反应：一项随机临床试验
Bone Joint J. 2017 Nov;99-B(11):1442-1449. doi: 10.1302/0301-620X.99B11.BJJ-2017-0488.R1.
8
No Correlation Between Serum Markers and Early Functional Outcome After Contemporary THA.当代全髋关节置换术后血清标志物与早期功能结果之间无相关性。
Clin Orthop Relat Res. 2017 Feb;475(2):452-462. doi: 10.1007/s11999-016-4904-2.
9
Association of obesity with inflammation and pain after total hip arthroplasty.肥胖与全髋关节置换术后炎症和疼痛的关系。
Clin Orthop Relat Res. 2014 May;472(5):1442-8. doi: 10.1007/s11999-013-3282-2.
10
Intraoperative periarticular injection can alleviate the inflammatory response and enhance joint function recovery after hip arthroplasty in elderly patients with osteoporotic femoral neck fractures.关节周围注射可减轻老年骨质疏松性股骨颈骨折患者髋关节置换术后的炎症反应，增强关节功能恢复。
Medicine (Baltimore). 2021 Feb 19;100(7):e24596. doi: 10.1097/MD.0000000000024596.

引用本文的文献

1
Cortisol stress response after musculoskeletal surgery: a narrative review.肌肉骨骼手术后的皮质醇应激反应：一项叙述性综述。
EFORT Open Rev. 2025 Apr 1;10(4):186-192. doi: 10.1530/EOR-2024-0126.
2
Influence of spinal anaesthesia on postoperative cognitive decline in elderly population undergoing hip surgeries: A prospective observational study.脊髓麻醉对接受髋关节手术的老年人群术后认知功能下降的影响：一项前瞻性观察研究。
Indian J Anaesth. 2023 Aug;67(8):736-739. doi: 10.4103/ija.ija_947_22. Epub 2023 Aug 15.
3
Regulation of Cortisol in Patients Undergoing Total Joint Arthoplasty.

本文引用的文献

1
Safety of Perioperative Glucocorticoids in Elective Noncardiac Surgery: A Systematic Review and Meta-analysis.择期非心脏手术围手术期糖皮质激素的安全性：一项系统评价和荟萃分析。
Anesthesiology. 2017 Feb;126(2):234-248. doi: 10.1097/ALN.0000000000001466.
2
A biomechanical, micro-computertomographic and histological analysis of the influence of diclofenac and prednisolone on fracture healing in vivo.双氯芬酸和泼尼松龙对体内骨折愈合影响的生物力学、显微计算机断层扫描及组织学分析
BMC Musculoskelet Disord. 2016 Sep 5;17(1):383. doi: 10.1186/s12891-016-1241-2.
3
The Effect of Perioperative Corticosteroids in Total Hip Arthroplasty: A Prospective Double-Blind Placebo Controlled Pilot Study.
全关节成形术后患者皮质醇的调节。
Clin Appl Thromb Hemost. 2021 Jan-Dec;27:1076029621987614. doi: 10.1177/1076029621987614.
围手术期皮质类固醇在全髋关节置换术中的作用：一项前瞻性双盲安慰剂对照试验研究
J Arthroplasty. 2016 Jun;31(6):1208-1212. doi: 10.1016/j.arth.2015.11.011. Epub 2015 Dec 17.
4
Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis.软骨衰老：定义、特征及其在骨关节炎发病机制中的潜在作用。
Maturitas. 2015 Mar;80(3):237-44. doi: 10.1016/j.maturitas.2014.12.003. Epub 2014 Dec 24.
5
The clinical significance of an elevated postoperative glucose value in nondiabetic patients after colorectal surgery: evidence for the need for tight glucose control?结直肠手术后非糖尿病患者术后高血糖值的临床意义：是否需要严格控制血糖？
Ann Surg. 2013 Oct;258(4):599-604; discussion 604-5. doi: 10.1097/SLA.0b013e3182a501e3.
6
Dexamethasone reduces length of hospitalization and improves postoperative pain and nausea after total joint arthroplasty: a prospective, randomized controlled trial.地塞米松可缩短全关节置换术后的住院时间，并改善术后疼痛和恶心：一项前瞻性、随机对照试验。
J Arthroplasty. 2013 Sep;28(8 Suppl):11-7. doi: 10.1016/j.arth.2013.05.041. Epub 2013 Aug 9.
7
The hallmarks of aging.衰老的特征。
Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039.
8
Effects of dexamethasone on local infiltration analgesia in total knee arthroplasty: a randomized controlled trial.地塞米松对全膝关节置换术局部浸润镇痛的影响：一项随机对照试验。
Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1638-43. doi: 10.1007/s00167-013-2367-5. Epub 2013 Jan 11.
9
Statins, glucocorticoids, and nonsteroidal anti-inflammatory drugs: their influence on implant healing.他汀类药物、糖皮质激素和非甾体抗炎药：它们对种植体愈合的影响。
Implant Dent. 2012 Oct;21(5):362-7. doi: 10.1097/ID.0b013e3182611ff6.
10
Single dose dexamethasone for postoperative nausea and vomiting--a matched case-control study of postoperative infection risk.单剂量地塞米松用于术后恶心呕吐——术后感染风险的配对病例对照研究
Anaesth Intensive Care. 2010 Jul;38(4):661-6. doi: 10.1177/0310057X1003800407.