Department of Periodontics, Faculty of Dentistry, National University of Singapore, Singapore.
Implant Dent. 2012 Oct;21(5):362-7. doi: 10.1097/ID.0b013e3182611ff6.
This article aimed at exploring the effects of common systemic medications used in the United States and their effects on periimplant bone healing. An electronic search for articles evaluating the influence of systemic medications on periimplant bone healing was conducted using the PubMed (MEDLINE) database. Statins, when administered locally or systemically, were found to increase bone formation and density. A reduction in bone turnover and bone-to-implant contact was observed in animal models examining the effect of glucocorticoids on periimplant bone healing. Continued use of nonsteroidal anti-inflammatory drugs (NSAIDs) during or after implant placement was associated with reduced bone-to-implant contact, bone area, and bone density. Evidence seems to suggest that statins improve implant osseointegration. However, glucocorticoids and NSAIDs showed conflicting results. Therefore, more randomized clinical trials are needed to validate the effect of glucocorticoids and NSAIDs on periimplant bone healing.
本文旨在探讨美国常用的系统性药物及其对种植体周围骨愈合的影响。通过 PubMed（MEDLINE）数据库对评估系统性药物对种植体周围骨愈合影响的文章进行了电子检索。研究发现，他汀类药物局部或全身给药可增加骨形成和密度。在研究糖皮质激素对种植体周围骨愈合影响的动物模型中，观察到骨转换和骨-种植体接触减少。在种植体放置期间或之后继续使用非甾体抗炎药（NSAIDs）与骨-种植体接触减少、骨面积和骨密度降低有关。有证据表明，他汀类药物可改善种植体骨整合。然而，糖皮质激素和 NSAIDs 的结果却相互矛盾。因此，需要更多的随机临床试验来验证糖皮质激素和 NSAIDs 对种植体周围骨愈合的影响。
