超重女性身体活动代谢反应：随机临床试验。

Metabolic Reponses to a physical exercise session in women with excess body mass: randomized clinical trial.

机构信息

College Adventist Bahia, Cachoeira, Bahia, Brazil.

Bahian School of Medicine and Public Health, Science Development Foundation of Bahia, Bahia, Brazil.

出版信息

Lipids Health Dis. 2017 Dec 19;16(1):249. doi: 10.1186/s12944-017-0600-9.

DOI:10.1186/s12944-017-0600-9

PMID:29258520

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5735600/

Abstract

BACKGROUND

There are various factors that influence the effect of physical exercise on the lipid profile, among them the body mass index and calorie expenditure of the exercise are some of the main factors. To test the hypothesis that a physical exercise session based on caloric expenditure may acutely modify the glycemia and lipid values of women with excess body mass.

METHODS

The study included 66 women, randomly divided into two groups, control and experimental, with BMI of 29 ± 4.4 kg/m vs 29 ± 4.3 kg/m (p = 0.45) sedentary and aged 23 ± 3.8 vs 24 ± 3.5 years, respectively (p = 0.25). After 12 h fasting, the volunteers underwent the first blood collection. The experimental group was submitted to a physical exercise session corresponding to energy expenditure of 250Kcal, of light intensity based the Borg Rating of Perceived Exertion (RPE), 12 h after the first blood collection. The control and experimental group volunteers underwent a second blood collection 24 h after the first. Glycemia, insulin status and lipid profile were measured and Homa IR and Homa-beta were calculated. The t-test for independent and dependent samples was used, and a level of significance of 5% was adopted.

RESULTS

Physical exercise changed the glycemic response in both the intragroup analysis (before = 96 ± 6.6 mg/dL vs after = 92 ± 6.6 mg/dL), (p = 0.01), and in the intergroup analysis (control = Δ 0.9 ± 6.1 vs experimental = Δ -4.1 ± 6.3) (p = 0.02). No changes were shown for the Homa IR, Homa Beta and Insulin indexes. When the lipid profiles were evaluated, differences in HDL were shown in the intragroup analysis (before = 89 ± 10.5 mg/dL vs. after = 91 ± 10.3 mg/dL) (p = 0.04). For the other parameters (LDL, TG, Total Cholesterol, TG/HDL), no changes were shown.

CONCLUSION

In women with excess body weight, a low intensity exercise session diminished the glycemia, but did not change the lipid response.

TRIAL REGISTRATION

NCT03170973 . Retrospectively registered.

摘要

背景

有许多因素会影响体育锻炼对血脂谱的影响，其中，身体质量指数和运动的热量消耗是一些主要因素。本研究旨在测试以下假设，即基于热量消耗的体育锻炼可能会急性改变超重女性的血糖和血脂值。

方法

本研究纳入了 66 名女性，随机分为对照组和实验组，两组的 BMI 分别为 29±4.4kg/m2和 29±4.3kg/m2（p=0.45），静息状态下的年龄分别为 23±3.8 岁和 24±3.5 岁（p=0.25）。禁食 12 小时后，志愿者进行第一次采血。实验组志愿者进行一次能量消耗为 250kcal 的轻强度体育锻炼，根据 Borg 感知用力评分（RPE）进行评定，第一次采血后 12 小时进行。对照组和实验组志愿者在第一次采血后 24 小时进行第二次采血。检测血糖、胰岛素状态和血脂谱，并计算 Homa IR 和 Homa-beta。采用独立样本 t 检验，采用 5%的显著性水平。

结果

在组内分析中，体育锻炼改变了血糖反应（之前=96±6.6mg/dL，之后=92±6.6mg/dL）（p=0.01），并在组间分析中改变了血糖反应（对照组=Δ0.9±6.1，实验组=Δ-4.1±6.3）（p=0.02）。Homa IR、Homa Beta 和胰岛素指数没有变化。当评估血脂谱时，在组内分析中观察到 HDL 差异（之前=89±10.5mg/dL，之后=91±10.3mg/dL）（p=0.04）。对于其他参数（LDL、TG、总胆固醇、TG/HDL），没有变化。