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脑活动与针刺即时效应相关的受试者间同步分析:一项 fMRI 研究。

Intersubject synchronisation analysis of brain activity associated with the instant effects of acupuncture: an fMRI study.

机构信息

School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China.

出版信息

Acupunct Med. 2018 Feb;36(1):14-20. doi: 10.1136/acupmed-2016-011327. Epub 2017 Dec 19.

Abstract

OBJECTIVE

To use a promising analytical method, namely intersubject synchronisation (ISS), to evaluate the brain activity associated with the instant effects of acupuncture and compare the findings with traditional general linear model (GLM) methods.

METHODS

30 healthy volunteers were recruited for this study. Block-designed manual acupuncture stimuli were delivered at SP6, and sensations were measured after acupuncture stimulation. All subjects underwent functional MRI (fMRI) scanning during the acupuncture stimuli. The fMRI data were separately analysed by ISS and traditional GLM methods.

RESULTS

All subjects experienced sensations. ISS analysis showed that the regions activated during acupuncture stimulation at SP6 were mainly divided into five clusters based on the time courses. The time courses of clusters 1 and 2 were in line with the acupuncture stimulation pattern, and the active regions were mainly involved in the sensorimotor system and salience network. Clusters 3, 4 and 5 displayed an almost contrary time course relative to the stimulation pattern. The brain regions activated included the default mode network, descending pain modulation pathway and visual cortices. GLM analysis indicated that the brain responses associated with the instant effects of acupuncture were largely implicated in sensory and motor processing and sensory integration.

CONCLUSION

The ISS analysis considered the sustained effect of acupuncture and uncovered additional information not shown by GLM analysis. We suggest that ISS may be a suitable approach to investigate the brain responses associated with the instant effects of acupuncture.

摘要

目的

采用一种有前景的分析方法,即受试者间同步(ISS),评估与针刺即时效应相关的大脑活动,并将结果与传统的一般线性模型(GLM)方法进行比较。

方法

本研究招募了 30 名健康志愿者。在 SP6 处进行了块设计手动针刺刺激,针刺刺激后测量感觉。所有受试者在针刺刺激期间接受功能磁共振成像(fMRI)扫描。fMRI 数据分别通过 ISS 和传统 GLM 方法进行分析。

结果

所有受试者均体验到了 感觉。ISS 分析显示,SP6 针刺刺激期间激活的区域主要根据时间过程分为五个簇。簇 1 和 2 的时间过程与针刺刺激模式一致,活跃区域主要涉及感觉运动系统和突显网络。簇 3、4 和 5 显示出与刺激模式几乎相反的时间过程。激活的脑区包括默认模式网络、下行疼痛调节通路和视觉皮层。GLM 分析表明,与针刺即时效应相关的大脑反应主要涉及感觉和运动处理以及感觉整合。

结论

ISS 分析考虑了针刺的持续效应,并揭示了 GLM 分析未显示的额外信息。我们建议,ISS 可能是研究与针刺即时效应相关的大脑反应的一种合适方法。

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