p53基因密码子72多态性与精子参数的关系。一项关于精索静脉曲张男性的研究。
The relationship between p53 codon 72 genetic polymorphism and sperm parameters. A study of men with varicocele.
作者信息
Gentile V, Nicotra M, Minucci S, Ambrosi S, Saccucci P, Gloria-Bottini F, Bottini E
机构信息
Department of Gynaecologic, Obstetric and Urologic Sciences University of Rome La Sapienza Rome Italy.
S. Camillo Hospital Rome Italy.
出版信息
Reprod Med Biol. 2014 Jul 29;14(1):11-15. doi: 10.1007/s12522-014-0188-y. eCollection 2015 Jan.
PURPOSE
Regulation of the apoptotic process has an important role in spermatogenesis. p53 has a prominent function in apoptosis and recent data suggest a relationship between varicocele and p53 codon 72 polymorphism and male infertility. This prompted us to study the relationship between this polymorphism and spermatic parameters.
METHODS
We studied 134 subjects with varicocele admitted consecutively to the outpatients Department of Infertility at the University of Rome La Sapienza. We investigated in these subjects the effect of a strong apoptosis inducer, the p53 codon 72 *Arg/*Arg genotype, on spermatic parameters.The p53 codon 72 genotype was determined by DNA analysis.
RESULTS
The proportion of spermatozoa with abnormal (curvilinear) motility is higher in men with the *Arg/*Arg genotype than in men carrying the *Pro allele ( = 0.003). No statistical significant relationship has been observed with spermatozoa concentration and atypical spermatozoa.
CONCLUSIONS
We conclude: the p53 codon 72*Arg/*Arg genotype, with its strong apoptotic effects, negatively influences spermatozoa motility and male fertility.
目的
凋亡过程的调控在精子发生中具有重要作用。p53在凋亡中发挥着显著作用，近期数据表明精索静脉曲张与p53密码子72多态性及男性不育之间存在关联。这促使我们研究这种多态性与精子参数之间的关系。
方法
我们研究了134例连续入住罗马第一大学不孕症门诊的精索静脉曲张患者。我们在这些受试者中研究了一种强烈的凋亡诱导剂——p53密码子72 *Arg/*Arg基因型对精子参数的影响。通过DNA分析确定p53密码子72基因型。
结果
*Arg/Arg基因型男性中具有异常（曲线）运动能力的精子比例高于携带Pro等位基因的男性（P = 0.003）。未观察到与精子浓度和非典型精子有统计学显著关系。
结论
我们得出结论：具有强烈凋亡作用的p53密码子72 *Arg/*Arg基因型对精子运动能力和男性生育能力有负面影响。
Zotero 插件